Only coherent spiking in posterior parietal cortex coordinates looking and reaching.

Only coherent spiking in posterior parietal cortex coordinates looking and reaching.
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DOI:
10.1016/j.neuron.2011.12.035
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发表时间:
2012-02-23
期刊:
影响因子:
16.2
通讯作者:
Pesaran B
Pesaran B
中科院分区:
医学1区
文献类型:
--
作者:
Dean HL;Hagan MA;Pesaran B

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在这里,我们报告了后顶叶皮层(PPC)的时间模式,连贯的尖峰活动协调了看和伸手的时间。使用尖峰场方法,我们确定了一群顶叶区LIP神经元,它们以15 Hz的β频率LFP活动相干地发射尖峰。相干活动神经元的放电速率预测协同到达-扫视运动的反应时间(RTs),而不是单独进行扫视运动的反应时间(RTs)。不一致放电的区域LIP神经元不能预测任何一种运动类型的RT。类似的β -波段LFP活动存在于顶叶到达区,但不存在于视觉区V3d附近。这表明PPC中连贯的尖峰活动可以同时控制到达和扫视。我们提出,协调的神经机制包括一个共同的表征,它共同减缓或加速运动。
Here, we report that temporally-patterned, coherent spiking activity in posterior parietal cortex (PPC) coordinates the timing of looking and reaching. Using a spike-field approach, we identify a population of parietal area LIP neurons that fire spikes coherently with 15 Hz beta frequency LFP activity. The firing rate of coherently-active neurons predicts the reaction times (RTs) of coordinated reach-saccade movements but not of saccades when made alone. Area LIP neurons that do not fire coherently do not predict RT of either movement type. Similar beta-band LFP activity is present in the parietal reach region but not nearby visual area V3d. This suggests that coherent spiking activity in PPC can control reaches and saccades together. We propose that the neural mechanism of coordination involves a shared representation that acts to slow or speed movements together.
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