The neurobiology of decision: consensus and controversy.

The neurobiology of decision: consensus and controversy.
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DOI:
10.1016/j.neuron.2009.09.003
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发表时间:
2009-09-24
期刊:
影响因子:
16.2
通讯作者:
Glimcher, Paul W.
Glimcher, Paul W.
中科院分区:
医学1区
文献类型:
--
作者:
Kable, Joseph W.;Glimcher, Paul W.

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我们回顾和综合最近的神经生理学研究的决策在人类和非人类灵长类动物。从这些研究中,灵长类动物选择的神经生物学机制的基本轮廓开始显现。目前已知的机制包括一个多成分评价阶段,在腹内侧前额叶皮层和纹状体的相关部分实施,以及一个选择阶段,在外侧前额叶和顶叶区域实施。决策的神经生物学研究开始增强我们对经济和社会行为的理解,以及我们对人们行为起关键作用的重大健康障碍的理解。
We review and synthesize recent neurophysiological studies of decision-making in humans and non-human primates. From these studies, the basic outline of the neurobiological mechanism for primate choice is beginning to emerge. The identified mechanism is now known to include a multi-component valuation stage, implemented in ventromedial prefrontal cortex and associated parts of striatum, and a choice stage, implemented in lateral prefrontal and parietal areas. Neurobiological studies of decision-making are beginning to enhance our understanding of economic and social behavior, as well as our understanding of significant health disorders where people’s behavior plays a key role.
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