Genetic mapping of Foxb1-cell lineage shows migration from caudal diencephalon to telencephalon and lateral hypothalamus.
Genetic mapping of Foxb1-cell lineage shows migration from caudal diencephalon to telencephalon and lateral hypothalamus.
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Foxb1细胞谱系的遗传图谱显示从尾部间脑迁移到端脑和外侧下丘脑
DOI：
10.1111/j.1460-9568.2008.06503.x
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发表时间：
2008-11
期刊：
影响因子：
--
通讯作者：
Alvarez-Bolado G
中科院分区：
文献类型：
--
作者：
Zhao T;Szabó N;Ma J;Luo L;Zhou X;Alvarez-Bolado G
下丘脑是一个具有重要功能的大脑区域，其发育的改变可能导致人类疾病。然而，我们仍然没有一个完整的描述，这个复杂的结构是如何在胚胎和出生后早期阶段放在一起。放射状定向的细胞由外向内迁移在发育中的下丘脑中普遍存在。尽管如此，下丘脑外的细胞特遣队以及切线下丘脑迁移也有重要作用。在这里，我们研究移民在下丘脑原基的基因标记Foxb1间脑谱系。Foxb1是一种转录因子基因，在发育中的神经管的神经上皮中表达，在尾侧和头侧间脑之间具有头侧表达边界，因此适合标记从尾侧水平迁移到下丘脑。我们已经发现了一个大的，纵向取向的迁移流显然起源于丘脑区域和轴突束结束在下丘脑外侧区的前部。此外，我们还绘制了一个特定的扩张的神经上皮到喙间脑。扩张的神经上皮细胞在结节水平为内侧下丘脑产生丰富的神经元。最后，我们发现了间脑到端脑迁移到中隔、梨状皮质和杏仁核的新现象。
The hypothalamus is a brain region with vital functions, and alterations in its development can cause human disease. However, we still do not have a complete description of how this complex structure is put together during embryonic and early postnatal stages. Radially oriented, outside‐in migration of cells is prevalent in the developing hypothalamus. In spite of this, cell contingents from outside the hypothalamus as well as tangential hypothalamic migrations also have an important role. Here we study migrations in the hypothalamic primordium by genetically labeling the Foxb1 diencephalic lineage. Foxb1 is a transcription factor gene expressed in the neuroepithelium of the developing neural tube with a rostral expression boundary between caudal and rostral diencephalon, and therefore appropriate for marking migrations from caudal levels into the hypothalamus. We have found a large, longitudinally oriented migration stream apparently originating in the thalamic region and following an axonal bundle to end in the anterior portion of the lateral hypothalamic area. Additionally, we have mapped a specific expansion of the neuroepithelium into the rostral diencephalon. The expanded neuroepithelium generates abundant neurons for the medial hypothalamus at the tuberal level. Finally, we have uncovered novel diencephalon‐to‐telencephalon migrations into septum, piriform cortex and amygdala.
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影响因子：
64.5
作者：
CHENN, A;MCCONNELL, SK
通讯作者：
MCCONNELL, SK
影响因子：
3.4
作者：
Amiot, C;Brischoux, F;Risold, PY
通讯作者：
Risold, PY
影响因子：
2.7
作者：
ArnoldAldea, SA;Cepko, CL
通讯作者：
Cepko, CL
DOI：
10.1073/pnas.89.2.693
发表时间：
1992-01-15
影响因子：
11.1
作者：
FIELDSBERRY, SC;HALLIDAY, AL;CEPKO, CL
通讯作者：
CEPKO, CL
影响因子：
16.2
作者：
Gustincich, S;Feigenspan, A;Raviola, E
通讯作者：
Raviola, E