Metabolic risk factors and mechanisms of disease in epithelial ovarian cancer: A review.
Metabolic risk factors and mechanisms of disease in epithelial ovarian cancer: A review.
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DOI：
10.1016/j.ygyno.2016.10.005
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发表时间：
2016-12
影响因子：
4.7
通讯作者：
Arend RC
中科院分区：
文献类型：
--
作者：
Craig ER;Londoño AI;Norian LA;Arend RC
上皮性卵巢癌仍然是最致命的妇科恶性肿瘤。糖尿病和肥胖患者的预后较差，但缺乏将代谢异常（如代谢综合征）与卵巢癌风险和预后相关的研究。本文综述了有关代谢紊乱及其与上皮性卵巢癌的关系的文献，重点是这些协会背后的潜在机制。检索PubMed和Google Scholar中关于上皮性卵巢癌、肥胖、糖尿病和代谢综合征的英文文章，重点关注自1990年以来进行的研究。肥胖、II型糖尿病和代谢综合征与上皮性卵巢癌预后不良相关。需要更多的研究来调查代谢综合征和上皮性卵巢癌之间的关系。多种病理因素可能导致代谢紊乱患者的癌症风险，包括脂肪因子和细胞因子表达改变，对肿瘤细胞的免疫反应改变，以及促肿瘤发生信号通路的变化。需要更多的研究来检查代谢综合征对上皮性卵巢癌风险和死亡率的影响，以及肥胖、糖尿病和代谢综合征患者的潜在病理生理学，这些可能是治疗干预的目标。
Epithelial ovarian cancer continues to be the deadliest gynecologic malignancy. Patients with both diabetes mellitus and obesity have poorer outcomes, yet research correlating metabolic abnormalities, such as metabolic syndrome, to ovarian cancer risk and outcomes is lacking. This article reviews the literature regarding metabolic derangements and their relationship to epithelial ovarian cancer, with a focus on potential mechanisms behind these associations. PubMed and Google Scholar were searched for articles in the English language regarding epithelial ovarian cancer, obesity, diabetes mellitus, and metabolic syndrome, with a focus on studies conducted since 1990. Obesity, type II diabetes mellitus, and metabolic syndrome have been associated with poor outcomes in epithelial ovarian cancer. More studies investigating the relationship between metabolic syndrome and epithelial ovarian cancer are needed. A variety of pathologic factors may contribute to cancer risk in patients with metabolic derangements, including altered adipokine and cytokine expression, altered immune responses to tumor cells, and changes in pro-tumorigenic signaling pathways. More research is needed to examine the effects of metabolic syndrome on epithelial ovarian cancer risk and mortality, as well as the underlying pathophysiologies in patients with obesity, diabetes mellitus, and metabolic syndrome that may be targeted for therapeutic intervention.
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影响因子：
16.2
作者：
Esposito K;Chiodini P;Colao A;Lenzi A;Giugliano D
通讯作者：
Giugliano D
影响因子：
37.8
作者：
Alberti, K. G. M. M.;Eckel, Robert H.;Smith, Sidney C., Jr.
通讯作者：
Smith, Sidney C., Jr.
影响因子：
--
作者：
Kato S;Abarzua-Catalan L;Trigo C;Delpiano A;Sanhueza C;García K;Ibañez C;Hormazábal K;Diaz D;Brañes J;Castellón E;Bravo E;Owen G;Cuello MA
通讯作者：
Cuello MA
影响因子：
2.3
作者：
Iglay, Kristy;Hannachi, Hakima;Rajpathak, Swapnil
通讯作者：
Rajpathak, Swapnil
影响因子：
4.7
作者：
Colvin EK
通讯作者：
Colvin EK