Inflammation in subcutaneous adipose tissue: relationship to adipose cell size.
Inflammation in subcutaneous adipose tissue: relationship to adipose cell size.
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DOI：
10.1007/s00125-009-1496-3
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发表时间：
2010-03
期刊：
影响因子：
8.2
通讯作者：
Sherman A
中科院分区：
文献类型：
--
作者：
McLaughlin T;Deng A;Yee G;Lamendola C;Reaven G;Tsao PS;Cushman SW;Sherman A
炎症与体重增加有关，据称与脂肪细胞大小增加有关。我们的目标是确定脂肪细胞的大小增加是否与体重稳定的中度肥胖人群的局部炎症有关。招募了49名健康的中度肥胖个体进行胰岛素抵抗定量（改良胰岛素抑制试验）和皮下腹部脂肪组织活检。用Beckman Coulter Multisizer III分析细胞大小分布，用rtPCR分析炎性基因表达。计算了炎症基因表达与细胞大小参数之间的相关性，并对性别和胰岛素抵抗进行了调整。脂肪细胞呈双峰分布，其中47%的“大”细胞群，其余的“小”细胞群。大脂肪细胞的中位直径与炎症基因的表达无关。相反，小脂肪细胞的比例与炎症基因表达相关，与性别、胰岛素抵抗和BMI无关。这种关联在胰岛素抵抗者中比胰岛素敏感者更明显。胰岛素抵抗也与炎症基因的表达独立相关。这项研究表明，在中度肥胖、体重稳定的个体中，小脂肪细胞比例的增加与皮下脂肪组织中的炎症有关，而成熟脂肪细胞的大小则无关。观察到的小脂肪细胞和炎症之间的关联可能反映了受损的脂肪形成和/或终末分化，但这是否是炎症的原因或后果尚不清楚。这个问题以及小、大或总脂肪细胞群是否有助于炎症是未来研究的主题。
Inflammation is associated with increased body mass, and purportedly, increased size of adipose cells. Our goal was to determine if increased size of adipose cells, is associated with localized inflammation in weight-stable, moderately-obese humans. 49 healthy, moderately-obese individuals were recruited for quantification of insulin resistance (modified insulin suppression test) and subcutaneous abdominal adipose tissue biopsy. Cell size distribution was analyzed with Beckman Coulter Multisizer III, and inflammatory gene expression with rtPCR. Correlations between inflammatory gene expression and cell size parameters, with adjustment for gender and insulin resistance, were calculated. Adipose cells were bimodally distributed, with 47% in a “large” cell population, and the remainder in a “small” cell population. The median diameter of the large adipose cells was not associated with expression of inflammatory genes. Rather, the fraction of small adipose cells was associated with inflammatory gene expression, independent of gender, insulin resistance, and BMI. This association was more pronounced in insulin-resistant than insulin-sensitive individuals. Insulin resistance was also independently associated with expression of inflammatory genes. Ths study demonstrates that among moderately-obese, weight-stable individuals, an increased proportion of small adipose cells is associated with inflammation in subcutaneous adipose tissue, whereas size of mature adipose cells is not. The observed association between small adipose cells and inflammation may reflect impaired adipogenesis and/or terminal differentiation, but whether this is a cause or consequence of inflammation is unclear. This question and whether the small, large, or total adipose cell population contribute to the inflammation are topics for future research.
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影响因子：
4.8
作者：
Gustafson, B;Smith, U
通讯作者：
Smith, U
影响因子：
--
作者：
McLaughlin, Tracey;Abbasi, Fahim;Reaven, Gerald
通讯作者：
Reaven, Gerald
DOI：
10.1016/j.bbrc.2004.03.152
发表时间：
2004-05-14
影响因子：
3.1
作者：
Yang, XL;Jansson, PA;Smith, U
通讯作者：
Smith, U
影响因子：
7.7
作者：
GREENFIELD, MS;DOBERNE, L;REAVEN, G
通讯作者：
REAVEN, G
影响因子：
15.9
作者：
SHEN, SW;REAVEN, GM;FARQUHAR, JW
通讯作者：
FARQUHAR, JW