Microbiome influencers of checkpoint blockade-associated toxicity.
Microbiome influencers of checkpoint blockade-associated toxicity.
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DOI：
10.1084/jem.20220948
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发表时间：
2023-03-06
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影响因子：
--
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微生物组影响对免疫治疗的反应，包括检查点抑制剂的免疫相关不良事件（irAE）。Wang、Jenq等人通过关注主要细菌分类群、潜在免疫机制和微生物组调节治疗irAE的临床机会，讨论了微生物组对irAE的贡献。免疫疗法大大改善了癌症的预后，但这些治疗（包括免疫检查点抑制剂（ICI））可能会发生反应和脱靶组织损伤的变化。多种证据表明宿主微生物组影响ICI反应和免疫相关不良事件（irAE）的风险。由于微生物组是可改变的，这些进展表明有可能操纵微生物组组分以增加ICI的成功率。我们讨论了与ICI反应相关的微生物组特征，重点关注irAE中涉及的细菌分类群和潜在免疫机制，以及推动新方法来操纵微生物组以提高ICI疗效同时避免irAE风险的总体目标。
The microbiome influences response to immunotherapy, including immune-related adverse events (irAEs) with checkpoint inhibitors. Wang, Jenq, et al. discuss microbiome contributions to irAEs by focusing on major bacterial taxa, potential immune mechanisms, and clinical opportunities for microbiome modulation to treat irAEs. Immunotherapy has greatly improved cancer outcomes, yet variability in response and off-target tissue damage can occur with these treatments, including immune checkpoint inhibitors (ICIs). Multiple lines of evidence indicate the host microbiome influences ICI response and risk of immune-related adverse events (irAEs). As the microbiome is modifiable, these advances indicate the potential to manipulate microbiome components to increase ICI success. We discuss microbiome features associated with ICI response, with focus on bacterial taxa and potential immune mechanisms involved in irAEs, and the overall goal of driving novel approaches to manipulate the microbiome to improve ICI efficacy while avoiding irAE risk.
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影响因子：
30.3
作者：
Cao, Y. Grace;Bae, Sena;Villarreal, Jannely;Moy, Madelyn;Chun, Eunyoung;Michaud, Monia;Lang, Jessica K.;Glickman, Jonathan N.;Lobel, Lior;Garrett, Wendy S.
通讯作者：
Garrett, Wendy S.
影响因子：
64.5
作者：
Ang, Qi Yan;Alexander, Margaret;Turnbaugh, Peter J.
通讯作者：
Turnbaugh, Peter J.
影响因子：
4.6
作者：
Chang CC;Hayase E;Jenq RR
通讯作者：
Jenq RR
影响因子：
16.6
作者：
Dubin K;Callahan MK;Ren B;Khanin R;Viale A;Ling L;No D;Gobourne A;Littmann E;Huttenhower C;Pamer EG;Wolchok JD
通讯作者：
Wolchok JD
影响因子：
16.6
作者：
Burrello, Claudia;Garavaglia, Federica;Facciotti, Federica
通讯作者：
Facciotti, Federica