The effects of endurance exercise in hypoxia on acid-base balance and potassium kinetics: a randomized crossover design in male endurance athletes.
The effects of endurance exercise in hypoxia on acid-base balance and potassium kinetics: a randomized crossover design in male endurance athletes.
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DOI：
10.1186/s40798-018-0160-1
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发表时间：
2018-10-13
期刊：
影响因子：
--
通讯作者：
Goto K
中科院分区：
文献类型：
--
作者：
Sumi D;Kojima C;Kasai N;Goto K
运动引起的酸碱平衡紊乱和细胞外钾（K+）的积累被认为是引起疲劳的原因。与常氧运动相比，低氧条件下的运动可能会增强运动引起的这两个因素的变化。在本研究中，我们调查酸碱平衡和钾动力学的耐力运动员在中度低氧条件下的运动反应。9名中长跑运动员[最大摄氧量（VO 2 max）57.2 ± 1.0mL/kg/min]在不同的时间完成了两项不同的试验，包括中度低氧运动[吸入氧分数（FiO 2）= 14.5%，H试验]和常氧运动（FiO 2 = 20.9%，N试验）。他们在低氧或常氧条件下进行间歇性耐力运动（8 × 4分钟蹬踏，80%的VO 2 max，交替进行2分钟主动休息，40%的VO 2 max）。在运动前、运动中和运动后采集静脉血样本，以测定血液乳酸盐、pH值、碳酸氢根离子和K+浓度。在两项试验中，随着运动，血乳酸浓度显著增加。在所有时间点，N试验中胰岛素诱导的血乳酸升高均显著高于H试验（P = 0.012）。N试验中运动和运动后期间的二氢叶酸浓度（P = 0.001）和血液pH值（P = 0.019）显著低于H试验。在运动期间和运动后立即，N试验中产生的运动诱导的血K+浓度升高显著高于H试验（P = 0.03）。在中度低氧条件下，在自行车测力计上进行高强度间歇运动与在常氧条件下进行同等水平的运动相比，并未引起血液pH值降低或K+水平升高。
Exercise-induced disturbance of acid-base balance and accumulation of extracellular potassium (K+) are suggested to elicit fatigue. Exercise under hypoxic conditions may augment exercise-induced alterations of these two factors compared with exercise under normoxia. In the present study, we investigated acid-base balance and potassium kinetics in response to exercise under moderate hypoxic conditions in endurance athletes. Nine trained middle-to-long distance athletes [maximal oxygen uptake (VO2max) 57.2 ± 1.0 mL/kg/min] completed two different trials on different days, consisting of exercise in moderate hypoxia [fraction of inspired oxygen (FiO2) = 14.5%, H trial] and exercise in normoxia (FiO2 = 20.9%, N trial). They performed interval endurance exercise (8 × 4 min pedaling at 80% of VO2max alternated with 2-min intervals of active rest at 40% of VO2max) under hypoxic or normoxic conditions. Venous blood samples were obtained to determine blood lactate, pH, bicarbonate ion, and K+ concentrations before exercise, during exercise, and after exercise. The blood lactate concentrations increased significantly with exercise in both trials. Exercise-induced blood lactate elevations were significantly greater in the N trial than in the H trial at all time points (P = 0.012). Bicarbonate ion concentrations (P = 0.001) and blood pH (P = 0.019) during exercise and post-exercise periods were significantly lower in the N trial than in the H trial. A significantly greater exercise-induced elevation in blood K+ concentration was produced in the N trial than in the H trial during exercise and immediately after exercise (P = 0.03). High-intensity interval exercise on a cycle ergometer under moderate hypoxic conditions did not elicit a decrease in blood pH or elevation in K+ levels compared with an equivalent level of exercise under normoxic conditions.
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影响因子：
5.5
作者：
Street, D;Nielsen, JJ;Juel, C
通讯作者：
Juel, C
DOI：
10.1152/ajpcell.1997.273.2.c598
发表时间：
1997-08-01
影响因子：
5.5
作者：
Cairns, SP;Hing, WA;Loiselle, DS
通讯作者：
Loiselle, DS
影响因子：
--
作者：
SAHLIN, K;EDSTROM, L;HULTMAN, E
通讯作者：
HULTMAN, E
影响因子：
64.8
作者：
DAVIES, NW
通讯作者：
DAVIES, NW
影响因子：
3.7
作者：
Morishima T;Mori A;Sasaki H;Goto K
通讯作者：
Goto K