Impact of exercise and moderate hypoxia on glycemic regulation and substrate oxidation pattern.
Impact of exercise and moderate hypoxia on glycemic regulation and substrate oxidation pattern.
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DOI：
10.1371/journal.pone.0108629
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Goto K
中科院分区：
文献类型：
--
作者：
Morishima T;Mori A;Sasaki H;Goto K
我们研究了在白天7.5小时的中度缺氧条件下休息和运动时的代谢和内分泌反应。8名久坐、超重的男性（28.6±0.8 kg/m2）完成了四项实验：常氧休息试验（FiO2 = 20.9%, no - rest）、常氧运动试验（no - ex）、缺氧休息试验（FiO2 = 15.0%, hy - rest）和缺氧运动试验（hy - ex）。实验于8:00 ~ 15:30在环境箱中进行。在7.5 h内采集血液和呼吸气体样本。在运动试验中，受试者在8:00,10:30和13:00以60%的VO2max进行30分钟的蹬车运动，其余时间在每种环境中休息。标准膳食在8:30,11:00和13:30提供。超过7.5 h的血糖和血清胰岛素浓度曲线下的面积在四个试验中没有差异。在基线时，低氧试验中碳水化合物的贡献显著高于常氧试验（P<0.05）。尽管在no -ex和hy -ex试验中，运动促进了碳水化合物氧化，但hy -ex试验中每次运动和运动后碳水化合物的百分比贡献显著高于no -ex试验（P<0.05）。在7.5小时的中度缺氧条件下，三次30分钟的运动（60%的最大摄氧量）并没有减弱年轻超重男性的餐后血糖和胰岛素反应。然而，当运动在中度缺氧时，碳水化合物氧化显著增强。
We examined metabolic and endocrine responses during rest and exercise in moderate hypoxia over a 7.5 h time courses during daytime. Eight sedentary, overweight men (28.6±0.8 kg/m2) completed four experimental trials: a rest trial in normoxia (FiO2 = 20.9%, NOR-Rest), an exercise trial in normoxia (NOR-Ex), a rest trial in hypoxia (FiO2 = 15.0%, HYP-Rest), and an exercise trial in hypoxia (HYP-Ex). Experimental trials were performed from 8:00 to 15:30 in an environmental chamber. Blood and respiratory gas samples were collected over 7.5 h. In the exercise trials, subjects performed 30 min of pedaling exercise at 60% of VO2max at 8:00, 10:30, and 13:00, and rested during the remaining period in each environment. Standard meals were provided at 8:30, 11:00, and 13:30. The areas under the curves for blood glucose and serum insulin concentrations over 7.5 h did not differ among the four trials. At baseline, %carbohydrate contribution was significantly higher in the hypoxic trials than in the normoxic trials (P<0.05). Although exercise promoted carbohydrate oxidation in the NOR-Ex and HYP-Ex trials, %carbohydrate contribution during each exercise and post-exercise period were significantly higher in the HYP-Ex trial than in the NOR-Ex trial (P<0.05). Three sessions of 30 min exercise (60% of VO2max) in moderate hypoxia over 7.5 h did not attenuate postprandial glucose and insulin responses in young, overweight men. However, carbohydrate oxidation was significantly enhanced when the exercise was conducted in moderate hypoxia.
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影响因子：
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