Smoking, serum lipids, blood pressure, and sex differences in myocardial infarction. A 12-year follow-up of the Finnmark Study.
Smoking, serum lipids, blood pressure, and sex differences in myocardial infarction. A 12-year follow-up of the Finnmark Study.
复制标题
吸烟、血脂、血压和心肌梗死的性别差异。
DOI：
10.1161/01.cir.93.3.450
复制
发表时间：
1996
期刊：
影响因子：
37.8
通讯作者：
P. Lund
中科院分区：
文献类型：
--
作者：
I. Njølstad;E. Arnesen;P. Lund
背景
很少有流行病学研究调查同一研究人群中主要冠状动脉危险因素在两性中的相对重要性。特别是，目前还不清楚吸烟在男性和女性中是否具有类似的冠心病风险。
方法和结果
在一项以人群为基础的前瞻性研究中，研究了吸烟、血脂、血压和心肌梗死之间的关系，研究对象为年龄在35岁到52岁之间的11843名男性和女性。在12年中，495例首次心肌梗死为男性，103例为女性。男性的心肌梗死发病率是男性的4.6倍。与从不吸烟的人相比，每天至少抽20支烟的女性的发病率增加了6倍，男性的发病率增加了3倍，女性重度吸烟者的发病率超过了从不吸烟的男性。多变量分析表明，女性当前吸烟是一个更强的风险因素(相对风险为3.3；95%可信区间为2.1至5.1)，而男性为(相对风险为1.9；95%可信区间为1.6至2.3)。在45岁以下的人群中，与吸烟相关的性别差异更为明显(女性：相对风险，7.1；95%可信区间，2.6至19.1)(男性：相对风险，2.3；95%可信区间，1.6至3.2)。无论男女，血清总胆固醇、高密度脂蛋白胆固醇和收缩压也是非常显著的预测因子。
结论
吸烟是中年女性心肌梗死的一个比男性更强的危险因素。尽管心肌梗死发病率的性别差异很大，但与血脂和血压相关的相对风险相似。
BACKGROUND
Few epidemiological studies have investigated the relative importance of major coronary risk factors in the two sexes within the same study population. In particular, it is not clear whether smoking carries a similar risk of coronary heart disease in men and women.
METHODS AND RESULTS
The associations between smoking, serum lipids, blood pressure, and myocardial infarction were examined in a population-based prospective study of 11,843 men and women aged 35 to 52 years at entry. During 12 years, 495 cases of first myocardial infarction among men and 103 cases among women were identified. Myocardial infarction incidence was 4.6 times higher among men. The incidence was increased sixfold in women and threefold in men who smoked at least 20 cigarettes per day compared with never-smokers, and the rate in female heavy smokers exceeded that of never-smoking men. Multivariate analysis identified current smoking as a stronger risk factor in women (relative risk, 3.3; 95% confidence interval [CI], 2.1 to 5.1) than in men (relative risk, 1.9; 95% CI, 1.6 to 2.3). Among those under 45 years old at entry, the smoking-related sex difference was more pronounced (in women: relative risk, 7.1; 95% CI, 2.6 to 19.1) (in men: relative risk, 2.3; 95% CI, 1.6 to 3.2). Serum total cholesterol, HDL cholesterol, and systolic blood pressure were also highly significant predictors in both sexes.
CONCLUSIONS
Smoking was a stronger risk factor for myocardial infarction in middle-aged women than in men. Relative risks associated with serum lipids and blood pressure were similar despite large sex differences in myocardial infarction incidence rates.
DOI：
10.1097/00006254-198708000-00017
发表时间：
1986-11
期刊：
The New England journal of medicine
影响因子：
--
作者：
J. Michnovicz;R. Hershcopf;H. Naganuma;H. Bradlow;J. Fishman
通讯作者：
J. Michnovicz;R. Hershcopf;H. Naganuma;H. Bradlow;J. Fishman
口服避孕药的使用和心肌梗塞的风险。
影响因子：
5
作者：
Rosenberg,L;Palmer,JR;Lesko,SM;Shapiro,S
通讯作者：
Shapiro,S
影响因子：
158.5
作者：
GAZIANO, JM;BURING, JE;HENNEKENS, CH
通讯作者：
HENNEKENS, CH