Selective inflammatory propensities in adopted adolescents institutionalized as infants.
Selective inflammatory propensities in adopted adolescents institutionalized as infants.
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被收养的青少年在婴儿时期的选择性炎症倾向。
DOI：
10.1016/j.psyneuen.2020.105065
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发表时间：
2021-03
影响因子：
3.7
通讯作者：
Gunnar MR
中科院分区：
文献类型：
--
作者：
Engel ML;Coe CL;Reid BM;Donzella B;Gunnar MR
这项研究考察了早期生活逆境(ELA)是否与促炎细胞因子循环水平和细胞因子对三种刺激剂[脂多糖(LPS)、植物血凝素(PHA)和佛波酯加离子霉素(PMA/IO)]的反应增加有关。参与者以前是被机构收容的青年(N=45，女性56%)，在被收养到资源充足的家庭(收养时的中位年龄=13个月)和未被收养的对照(N=38，55%女性)之前，他们在机构照顾(如孤儿院、婴儿院)度过了第一年。年龄13.3~21.2岁(男性=16.3岁)。这项分析是对这些年轻人的早期报告(Reid等人，2019a)的后续研究，该报告发现，与NA年轻人相比，PI年轻人中终末分化的CD8+CD57 T细胞增加。循环中的细胞因子水平相关性不高，因此单独进行了检查。PI青年循环中肿瘤坏死因子-α(α)水平较高，而IL-1β(IL-1β)和IL-6(IL-6)无明显变化。在每种刺激剂条件下，细胞因子对体外激活的反应是高度相关的，因此结合起来产生了对每种刺激剂的炎症反应指数。经多因素协方差分析，PMA/IO条件下存在显著的多变量效应，PI青年比NA青年表现出更大的炎症反应。中介试验表明，CD8+CD5 7+α细胞是T细胞复制衰老的标志，在统计模型中，CD8+CD5 7+TEMRA细胞对循环中肿瘤坏死因子CD5 7的早期上调作用和PMA/IO反应性的综合炎症指数均起中介作用。循环IL-6和肿瘤坏死因子α水平也存在性别差异，男性高于女性。
This study examined whether early life adversity (ELA) limited to infancy was associated with an increase in circulating levels of proinflammatory cytokines and cellular cytokine responses to three stimulants [lipopolysaccharide (LPS), phytohemagglutinin (PHA), and phorbol myristate acetate plus ionomycin (PMA/IO)]. Participants were previously institutionalized (PI) youth (N = 45, 56% female) who had spent their first years in institutional care (e.g., orphanages, baby homes) before being adopted into well-resourced homes (median age at adoption = 13 mos) and non-adopted comparisons (NA; N =38, 55% female). Their age range was 13.3–21.2 years (M = 16.3 years). This analysis followed up an earlier report on these youth (Reid et al., 2019a) that identified an increase in terminally differentiated CD8+CD57 T cells among the PI relative to the NA youth. Cytokine levels in circulation were not highly correlated and thus examined separately. PI youth had higher circulating levels of Tumor Necrosis Factor-alpha (TNFα), but not Interleukin-1β (IL-1β) or Interleukin-6 (IL-6). Cytokine responses to in vitro activation within each stimulant condition were highly correlated and were thus combined to generate an index of the inflammatory reaction to each stimulant. Using Multivariate Analysis of Covariance, there was a highly significant multivariate effect of group, which was carried primarily by the PMA/IO condition, with PI youth exhibiting a larger inflammatory response than NA youth. Tests of mediation showed that both the early rearing effects on circulating TNFα and the composite inflammatory index of PMA/IO responsiveness were mediated in the statistical model by the percentage of CD8+CD57+ TEMRA cells in circulation, a marker of replicative senescence in T cells. Sex differences were also found in circulating levels of IL-6 and TNFα, with males having higher levels than females.
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影响因子：
4.4
作者：
Kruschinski, Carsten;Skripuletz, Thomas;von Hoersten, Stephan
通讯作者：
von Hoersten, Stephan
影响因子：
15.1
作者：
Fagundes, Christopher P.;Glaser, Ronald;Kiecolt-Glaser, Janice K.
通讯作者：
Kiecolt-Glaser, Janice K.
影响因子：
11
作者：
Baumeister D;Akhtar R;Ciufolini S;Pariante CM;Mondelli V
通讯作者：
Mondelli V
影响因子：
8.2
作者：
Coe, CL;Lubach, GR
通讯作者：
Lubach, GR
影响因子：
3
作者：
Hennessy, Michael B.;Schiml, Patricia A.;Deak, Terrence
通讯作者：
Deak, Terrence