High Gamma and Beta Temporal Interference Stimulation in the Human Motor Cortex Improves Motor Functions.
High Gamma and Beta Temporal Interference Stimulation in the Human Motor Cortex Improves Motor Functions.
复制标题
人体运动皮质中的高γ和β时间干扰刺激可改善运动功能。
DOI：
10.3389/fnins.2021.800436
复制
发表时间：
2021
影响因子：
4.3
通讯作者：
Zhang X
中科院分区：
文献类型：
--
作者：
Ma R;Xia X;Zhang W;Lu Z;Wu Q;Cui J;Song H;Fan C;Chen X;Zha R;Wei J;Ji GJ;Wang X;Qiu B;Zhang X
背景：时间干扰（TI）刺激是一种无创脑刺激的新技术。具有两个高频载波的包络调制波形可以激活目标大脑区域的神经元，而不刺激上层皮层，这已在小鼠大脑中得到验证。然而，TI刺激是否能够作用于人脑尚未得到阐明。目的：评估 TI 刺激的包络调制波形对人类初级运动皮层 (M1) 的有效性。方法：参与者在随机反应时间任务 (RRTT) 或连续反应时间任务 (SRTT) 期间参加了 3 次 30 分钟 TI 刺激。在 TI 刺激之前和之后测量运动皮层兴奋性。结果：在RRTT实验中，与假刺激相比，仅70 Hz TI刺激对反应时间（RT）表现和运动皮层兴奋性有促进作用。同时，与假条件相比，SRTT实验中仅20 Hz TI刺激显着促进了运动学习，与运动诱发电位的增加呈显着正相关。结论：这些结果表明TI刺激的包络调制波形对人体运动功能具有显着的促进作用，首次通过实验证明了TI刺激在人体中的有效性，并为进一步探索铺平了道路。
Background: Temporal interference (TI) stimulation is a new technique of non-invasive brain stimulation. Envelope-modulated waveforms with two high-frequency carriers can activate neurons in target brain regions without stimulating the overlying cortex, which has been validated in mouse brains. However, whether TI stimulation can work on the human brain has not been elucidated. Objective: To assess the effectiveness of the envelope-modulated waveform of TI stimulation on the human primary motor cortex (M1). Methods: Participants attended three sessions of 30-min TI stimulation during a random reaction time task (RRTT) or a serial reaction time task (SRTT). Motor cortex excitability was measured before and after TI stimulation. Results: In the RRTT experiment, only 70 Hz TI stimulation had a promoting effect on the reaction time (RT) performance and excitability of the motor cortex compared to sham stimulation. Meanwhile, compared with the sham condition, only 20 Hz TI stimulation significantly facilitated motor learning in the SRTT experiment, which was significantly positively correlated with the increase in motor evoked potential. Conclusion: These results indicate that the envelope-modulated waveform of TI stimulation has a significant promoting effect on human motor functions, experimentally suggesting the effectiveness of TI stimulation in humans for the first time and paving the way for further explorations.
登录
查看更多内容
影响因子：
4.8
作者：
Espenhahn S;Rossiter HE;van Wijk BCM;Redman N;Rondina JM;Diedrichsen J;Ward NS
通讯作者：
Ward NS
影响因子：
5.3
作者：
Feurra, Matteo;Pasqualetti, Patrizio;Rossi, Simone
通讯作者：
Rossi, Simone
影响因子：
4.6
作者：
Cao, Jiaming;Grover, Pulkit
通讯作者：
Grover, Pulkit
影响因子：
4.7
作者：
De Gennaro, L;Cristiani, R;Rossini, PM
通讯作者：
Rossini, PM
影响因子：
24.8
作者：
Doty, R W
通讯作者：
Doty, R W