TiO2/CeO2-CePO4-decorated enzymatic glucose biosensors operating in oxygen-restrictive environments
TiO2/CeO2-CePO4-decorated enzymatic glucose biosensors operating in oxygen-restrictive environments
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TiO2/CeO2-CePO4 修饰的酶促葡萄糖生物传感器在限氧环境中运行
DOI：
10.1007/s10008-021-04956-4
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发表时间：
2021-05
影响因子：
2.5
通讯作者：
Wang Zhifei
中科院分区：
文献类型：
--
作者：
Xu Jiawei;Yang Ke;Zhang Xuezhong;Lei Yunfeng;Meng Xiangyu;Wang Zhifei
血糖的检测在监测和控制糖尿病及其由高血糖水平引起的并发症中起着重要作用。葡萄糖传感器和集成柔性传感平台的研究已经很多，但在限氧环境下的检测报道很少。在此，我们描述了一种新的系统，由二氧化钛和氧化铈-磷酸铈（CeO 2-CePO 4）的复合纳米结构合成的一个简单的程序，以解决第一代电流型葡萄糖生物传感器所面临的氧依赖性问题。在富氧和限制性环境中测试传感器的酶活性。结果表明，所得复合材料对葡萄糖氧化具有良好的电催化活性。在富氧环境中，TiO 2/CeO 2-CePO 4修饰电极的线性范围为0.1 ~ 1.7mM，检出限为17.1 μM; CeO 2-CePO 4修饰电极的线性范围为0.1- 2.5mM，检出限为58.0 μM。两种修饰电极在限氧环境下均对葡萄糖有较好的响应，但前者的响应性能更好。所制备的电极具有良好的抗干扰性、稳定性和重现性。这种策略有望提高葡萄糖生物传感器的灵敏度，并为在氧气限制条件下的操作提供更多机会。
The detection of glucose plays an important role in monitoring and controlling diabetes as well as its complications caused by high blood glucose levels. There have been a lot of research on glucose sensors and integrated flexible sensing platforms; however, the detection in oxygen-restrictive environments is few reported. Herein, we described the use of a novel system made up of TiO2and ceria-cerium phosphate (CeO2-CePO4) composite nanostructures synthesized by a simple procedure to address the oxygen dependence problem confronted in the first-generation amperometric glucose biosensors. The enzymatic activity of sensors was tested in both oxygen-rich and restrictive environments. Our results showed that the resulting composites present good electro-catalytic activity towards glucose oxidation. The electrodes decorated by TiO2/CeO2-CePO4showed a wide linear range from 0.1 to 1.7 mM with a low detection limit of 17.1 μM while the CeO2-CePO4showed the linear range of 0.1–2.5 mM with limit of detection of 58.0 μM in oxygen-rich environment. Two types of decorated electrodes both responded to glucose well under the oxygen-restrictive environment but former showed better response performance. The as-fabricated electrodes also owned the good anti-interference, stability, and reproducibility. This strategy promises for increasing the sensitivity of glucose biosensors and provides more opportunities for operation in oxygen-restrictive conditions.Graphical abstract
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