Association of TCM body constitution with insulin resistance and risk of diabetes in impaired glucose regulation patients.
Association of TCM body constitution with insulin resistance and risk of diabetes in impaired glucose regulation patients.
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DOI：
10.1186/s12906-017-1964-0
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发表时间：
2017-09-11
影响因子：
--
通讯作者：
Gai Y
中科院分区：
文献类型：
--
作者：
You H;Zhang T;Feng W;Gai Y
血糖调节受损 (IGR) 患者患 2 型糖尿病 (T2DM) 的风险增加。识别 IGR 受试者的相关危险因素有助于早期发现和预防 IGR 进展为糖尿病。本研究探讨了中医体质与血清细胞因子之间的关系，以及体质是否可以独立预测 IGR 受试者的糖尿病。 IGR 患者 (n = 306) 接受了血液检查，并使用体质问卷 (BCQ) 评估了他们的体质类型。通过ELISA测量细胞因子的血清水平。对患者进行至少三年的随访，并记录他们的糖尿病状况。使用多变量逻辑回归来估计糖尿病与体质的比值比 (OR)。痰湿、湿热、气虚是IGR受试者最常见的三种不平衡体质。痰湿、湿热体质者血清白细胞介素6（IL-6）、肿瘤坏死因子-α（TNF-α）、瘦素水平较高，脂联素水平较低（P<0.05）。气虚体质者血清瘦素水平较高，脂联素、胰高血糖素样肽-1（GLP-1）、抑胃多肽（GIP）水平较低（P<0.05）。痰湿或湿热体质者患糖尿病的风险显着较高（P<0.05）。痰湿、湿热中医体质与血清细胞因子异常密切相关，可能作为 IGR 受试者糖尿病的预测因子。体质有助于识别 IGR 受试者是否有进展为糖尿病的高风险。
Impaired glucose regulation (IGR) patients have increased risk of type 2 diabetes mellitus (T2DM). Identifying relevant risk factors in IGR subjects could facilitate early detection and prevention of IGR progression to diabetes. This study investigated the association between Traditional Chinese Medicine (TCM) body constitution and serum cytokines, and whether body constitution could independently predict diabetes in IGR subjects. Patients with IGR (n = 306) received a blood test and their body constitution type was assessed using a body constitution questionnaire (BCQ). Serum levels of cytokines were measured by ELISA. Patients were followed up for at least three years, and their status of diabetes were recorded. Multivariate logistic regression was used to estimate odds ratios (ORs) of diabetes for body constitution. Phlegm-damp, Damp-heat and Qi-deficiency were three most common unbanlenced constitutions among IGR subjects. Phlegm-damp and Damp-heat constitution subjects showed higher serum levels of interleukin 6 (IL-6), tumour necrosis factor-α (TNF-α), leptin and lower serum levels of adiponectin (P<0.05). Qi-deficiency constitution subjects showed higher serum levels of leptin and lower serum levels of adiponectin, glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP) (P<0.05). Subjects with Phlegm-damp or Damp-heat constitution demonstrated a significantly higher risk of diabetes (P<0.05). Phlegm-damp and Damp-heat TCM body constitution are strongly associated with abnormal serum cytokines, and could potentially serve as a predictor of diabetes in IGR subjects. Body constitution can help to identify IGR subjects who are at a high risk of progression to diabetes.
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DOI：
10.1136/bmj.e3564
发表时间：
2012-06-07
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Lee M;Saver JL;Hong KS;Song S;Chang KH;Ovbiagele B
通讯作者：
Ovbiagele B
影响因子：
3.1
作者：
Huang, Shan;Zou, Dajin;Tang, Yubin
通讯作者：
Tang, Yubin
DOI：
10.1155/2013/793820
发表时间：
2013
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Dai J;Sun S;Cao J;Zhao Y;Cao H;Zheng N;Fang J;Wang Y;Zhang W;Zhang Y;Hu Y;Cao Z
通讯作者：
Cao Z
影响因子：
3.7
作者：
Vasu S;Moffett RC;Thorens B;Flatt PR
通讯作者：
Flatt PR
影响因子：
2.1
作者：
Chiang, Hui-Chu;Chang, Hen-Hong;Hsu, Mutsu
通讯作者：
Hsu, Mutsu