Neurophysiological and behavioural effects of conventional and high definition tDCS.
Neurophysiological and behavioural effects of conventional and high definition tDCS.
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DOI：
10.1038/s41598-021-87371-z
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发表时间：
2021-04-07
影响因子：
4.6
通讯作者：
Mapelli D
中科院分区：
文献类型：
--
作者：
Masina F;Arcara G;Galletti E;Cinque I;Gamberini L;Mapelli D
高清经颅直流电刺激（HD-tDCS）似乎克服了传统双极tDCS的缺点：电场的广泛扩散。然而，这两种技术的大部分差异都是基于数学模拟，而不是基于真实的行为和神经生理数据。该研究旨在比较广泛的tDCS蒙太奇（即，a具有脑外回流电极的传统双极导联）和HD-tDCS，研究在行为水平（就灵巧性表现而言）和神经生理水平（如EEG测量的α和β功率的修改）的差异。30名参与者参加了三个阶段，每个蒙太奇一个：传统tDCS，HD-tDCS和假手术。在所有条件下，将阳极放置在C4上，而阴极根据蒙太奇放置。在基线时，在每个刺激条件期间和之后，用手指敲击任务评估灵巧性。此外，在基线和刺激后记录静息状态EEG。计算功率谱密度，选择两个频带：α（8-12 Hz）和β（18-22 Hz）。使用线性混合效应模型（Linear mixed effect models，LIFE）来分析由tDCS诱导的调制。为了评价导联之间的差异并考虑状态依赖性现象，对刺激后测量值进行了基线水平的协变量调整。我们观察到HD-tDCS在基线时具有较低α的参与者中诱导α功率降低。相反，传统tDCS在基线时具有较高β的参与者中诱导β功率降低。此外，数据显示HD-tDCS在基线时具有较低β的参与者中具有行为效应的趋势，显示更快的响应时间。常规和HD-tDCS明显调制皮质活动。该研究强调了考虑状态依赖性以确定tDCS对个体的影响的重要性。
High-definition transcranial direct current stimulation (HD-tDCS) seems to overcome a drawback of traditional bipolar tDCS: the wide-spread diffusion of the electric field. Nevertheless, most of the differences that characterise the two techniques are based on mathematical simulations and not on real, behavioural and neurophysiological, data. The study aims to compare a widespread tDCS montage (i.e., a Conventional bipolar montage with extracephalic return electrode) and HD-tDCS, investigating differences both at a behavioural level, in terms of dexterity performance, and a neurophysiological level, as modifications of alpha and beta power as measured with EEG. Thirty participants took part in three sessions, one for each montage: Conventional tDCS, HD-tDCS, and sham. In all the conditions, the anode was placed over C4, while the cathode/s placed according to the montage. At baseline, during, and after each stimulation condition, dexterity was assessed with a Finger Tapping Task. In addition, resting-state EEG was recorded at baseline and after the stimulation. Power spectrum density was calculated, selecting two frequency bands: alpha (8–12 Hz) and beta (18–22 Hz). Linear mixed effect models (LMMs) were used to analyse the modulation induced by tDCS. To evaluate differences among the montages and consider state-dependency phenomenon, the post-stimulation measurements were covariate-adjusted for baseline levels. We observed that HD-tDCS induced an alpha power reduction in participants with lower alpha at baseline. Conversely, Conventional tDCS induced a beta power reduction in participants with higher beta at baseline. Furthermore, data showed a trend towards a behavioural effect of HD-tDCS in participants with lower beta at baseline showing faster response times. Conventional and HD-tDCS distinctively modulated cortical activity. The study highlights the importance of considering state-dependency to determine the effects of tDCS on individuals.
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影响因子：
5.7
作者：
Edwards, Dylan;Cortes, Mar;Datta, Abhishek;Minhas, Preet;Wassermann, Eric M.;Bikson, Marom
通讯作者：
Bikson, Marom
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
Angius L;Mauger AR;Hopker J;Pascual-Leone A;Santarnecchi E;Marcora SM
通讯作者：
Marcora SM
影响因子：
7.7
作者：
Bortoletto, Marta;Pellicciari, Maria Concetta;Miniussi, Carlo
通讯作者：
Miniussi, Carlo
影响因子：
7.7
作者：
Hill, Aron T.;Rogasch, Nigel C.;Hoy, Kate E.
通讯作者：
Hoy, Kate E.