Generic sensor platform based on electro-responsive molecularly imprinted polymer nanoparticles (e-NanoMIPs).
Generic sensor platform based on electro-responsive molecularly imprinted polymer nanoparticles (e-NanoMIPs).
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DOI：
10.1038/s41378-020-00193-3
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发表时间：
2020
影响因子：
7.9
通讯作者：
Piletsky SA
中科院分区：
文献类型：
--
作者：
Garcia-Cruz A;Ahmad OS;Alanazi K;Piletska E;Piletsky SA
本研究描述了基于电响应性分子印迹聚合物纳米颗粒(e-MIP)的健壮电化学传感器的设计。用氧化还原探针标记的电子MIP结合了识别和报告功能。该系统取代了传统生物传感器中使用的酶-介体对。当e-MIP的聚合物构象随着模板分析物的存在而改变时，分析物识别过程依赖于一般的驱动现象。用伏安法测定分析物浓度。在这项技术的一个例证中，开发了用于测定胰酶、葡萄糖、扑热息痛、C4-高丝氨酸内酯和THC浓度的电化学传感器。目前的技术使得生产用于临床、环境和法医应用的通用、廉价和坚固的一次性传感器成为可能。基于电活性分子印迹聚合物纳米颗粒(e-MIP)，分子印迹(在聚合物中创建模板形状的识别位点)应用于纳米颗粒，设计了强大的通用电化学传感器。在过去的十年中，商用生物传感器技术取得了显著的进步，但葡萄糖生物传感器仍然占据着世界生物传感器市场的压倒性多数。然而，由英国莱斯特大学的Alvaro Garcia-Cruz和Sergey Piletsky领导的一个团队已经成功地设计出了使用电子MIP的电化学传感器。E-MIP在一个系统中结合了识别和报告功能，取代了传统生物传感器使用的酶-介体对。易于生产和成本效益是这项技术相对于传统传感器的主要技术优势。作者认为，他们的系统在生产临床、环境和法医应用的通用、廉价和坚固的一次性传感器方面具有相当大的潜力。
The present research describes the design of robust electrochemical sensors based on electro-responsive molecularly imprinted polymer nanoparticles (e-MIPs). The e-MIPs, tagged with a redox probe, combine both recognition and reporting functions. This system replaces enzyme-mediator pairs used in traditional biosensors. The analyte recognition process relies on the generic actuation phenomenon when the polymer conformation of e-MIPs is changing in response to the presence of the template analyte. The analyte concentration is measured using voltammetric methods. In an exemplification of this technology, electrochemical sensors were developed for the determination of concentrations of trypsin, glucose, paracetamol, C4-homoserine lactone, and THC. The present technology allows for the possibility of producing generic, inexpensive, and robust disposable sensors for clinical, environmental, and forensic applications. Robust generic electrochemical sensors have been designed based on electroactive molecularly imprinted polymer nanoparticles (e-MIPs), in which molecular imprinting (creating template-shaped recognition sites in polymers) is applied to nanoparticles. Commercial biosensor technology has made remarkable advances over the past decade, but glucose biosensors still account for the overwhelming majority of the world biosensor market. However, a team headed by Alvaro Garcia-Cruz and Sergey Piletsky at the University of Leicester, United Kingdom has succeeded in designing electrochemical sensors employing e-MIPs. The e-MIPs combine both recognition and reporting functions in a system that replaces the enzyme-mediator pairs used with conventional biosensors. Ease of production and cost efficiency are major technological advantages of this technology over traditional sensors. The authors believe that their system has considerable potential for producing generic, inexpensive, and robust disposable sensors for clinical, environmental, and forensic applications.
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影响因子：
3.9
作者：
Poma A;Guerreiro A;Caygill S;Moczko E;Piletsky S
通讯作者：
Piletsky S
影响因子：
12.6
作者：
Canfarotta, Francesco;Czulak, Joanna;Mattiasson, Bo
通讯作者：
Mattiasson, Bo
影响因子：
8.4
作者：
Garcia-Mutio, D.;Gomez-Caballero, A.;Barrioa, R. J.
通讯作者：
Barrioa, R. J.
影响因子：
8.4
作者：
Prasad, K.;Prathish, K. P.;Rao, T. Prasada
通讯作者：
Rao, T. Prasada
影响因子：
4.6
作者：
Rangel, Paulina X. Medina;Lacief, Sylvain;Haupt, Karsten
通讯作者：
Haupt, Karsten