Landscape of gut microbiota and metabolites and their interaction in comorbid heart failure and depressive symptoms: a random forest analysis study.
Landscape of gut microbiota and metabolites and their interaction in comorbid heart failure and depressive symptoms: a random forest analysis study.
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DOI：
10.1128/msystems.00515-23
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发表时间：
2023-12-21
期刊：
影响因子：
6.4
通讯作者：
中科院分区：
文献类型：
--
作者：
抑郁是心力衰竭（HF）患者预后不良的个体危险因素。最近的研究表明，肠道微生物群和代谢产物在共病HF和抑郁症状中起着关键作用。我们招募了95名受试者，包括35名有抑郁症状的HF患者（HF-DS），36名无抑郁症状的HF患者（HF-NDS）和24名健康对照（HC）。采用16 S rRNA、宏基因组测序和非靶向代谢组学分析来测试粪便样品。我们的分析发现，HF-DS、HF-NDS和HC人群的肠道微生物群组成存在显著差异。在属的水平上，与HF-NDS患者相比，HF-DS患者中的Meditrilea，Tolumona和Parabacteroides显著增加，而Pedobacter，Azoyllum和Ruminiclostridium显著减少。此外，抗炎介质（松香酸，奎尼酸，亚油酸等）和神经递质（儿茶素、5-羟色胺、色胺、苯乙胺等）在HF-DS中减少。富集分析显示，肠道菌群高度符合代谢物的功能途径，氨基酸相关代谢、脂肪酸相关代谢和cAMP信号通路可能是参与抑郁症和HF共病发展的重要生物学机制。最后，将梭菌属和α-生育酚确定为HF-DS患者的诊断标志物。越来越多的证据表明，肠道微生物组成和功能的改变与心血管或精神疾病有关。因此，研究具有抑郁症状的HF患者的微生物群的分类和功能特征是有意义的。在这项横断面研究中，将梭菌属和α-生育酚确定为新的诊断标志物。此外，肠道微生态系统障碍与HF患者的抑郁症状密切相关，为理解肠-心/脑轴提供了新的参考观点。
Depression is an individual risk factor for poor prognosis in patients with heart failure (HF). Recent studies show that gut microbiota and metabolites play a critical role in comorbid HF and depressive symptoms. We recruited 95 subjects including 35 HF patients with depressive symptoms (HF-DS), 36 HF patients without depressive symptoms (HF-NDS), and 24 healthy controls (HC). The 16S rRNA, metagenome sequencing, and untargeted metabolomic analysis were employed to test fecal samples. Our analysis found a significant difference in composition of gut microbiota in HF-DS, HF-NDS, and HC populations. At the genus level, Mediterranea, Tolumona, and Parabacteroides were significantly increased in HF-DS patients compared with HF-NDS patients, while Pedobacter, Azospirillum, and Ruminiclostridium were significantly decreased. Furthermore, anti-inflammatory mediators (abietic acid, quinic acid, linoleic acid, etc.) and neurotransmitters (catechin, serotonin, tryptamine, phenylethylamine, etc.) were reduced in HF-DS. The enrichment analysis revealed that the gut microbiota highly conformed to the functional pathways of metabolites, and amino acid-related metabolism, fatty acid-related metabolism, and cAMP signaling pathways may be crucial biological mechanisms involved in the development of comorbid depression and HF. Finally, Cloacibacillus and alpha-tocopherol were determined as diagnostic markers for HF-DS patients. There is increasing evidence that alterations in gut microbial composition and function are associated with cardiovascular or psychiatric disease. Therefore, it is meaningful to investigate the taxonomic and functional characterization of the microbiota in HF patients who also have depressive symptoms. In this cross-sectional study, Cloacibacillus and alpha-tocopherol were determined as new diagnostic markers. Furthermore, intestinal microecosystem disorders are closely linked to depressive symptoms in HF patients, providing a new reference viewpoint for understanding the gut-heart/brain axis.
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影响因子：
12.3
作者：
Mallick H;Ma S;Franzosa EA;Vatanen T;Morgan XC;Huttenhower C
通讯作者：
Huttenhower C
影响因子：
14.9
作者：
Klindworth A;Pruesse E;Schweer T;Peplies J;Quast C;Horn M;Glöckner FO
通讯作者：
Glöckner FO
影响因子：
48
作者：
Langmead, Ben;Salzberg, Steven L.
通讯作者：
Salzberg, Steven L.
影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
DOI：
10.1073/pnas.1610325114
发表时间：
2017-07-25
影响因子：
11.1
作者：
McDougle, Daniel R.;Watson, Josephine E.;Das, Aditi
通讯作者：
Das, Aditi