Correlations of disease severity outcome measures in inclusion body myositis.
Correlations of disease severity outcome measures in inclusion body myositis.
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DOI：
10.1016/j.nmd.2022.08.005
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发表时间：
2022-10
影响因子：
2.8
通讯作者：
Mozaffar, Tahseen
中科院分区：
文献类型：
--
作者：
Goyal, Namita A.;Greenberg, Steven A.;Cauchi, Jonathan;Araujo, Nadia;Li, Vivian;Wencel, Marie;Irani, Tyler;Wang, Leo H.;Palma, Anton M.;Villalta, S. Armando;Mozaffar, Tahseen
本研究旨在评估包涵体肌炎（IBM）临床试验中用于评估疾病严重程度和进展的各种结局指标之间的相关性。一项横断面研究在加州大学欧文分校完成，涉及51名符合欧洲神经肌肉中心（ENMC） 2011年临床定义或可能的IBM标准的IBM患者。收集所有患者的临床详细资料、人口统计学数据和功能数据，包括定时起床（TGU）、手动肌肉测试、手握、捏压测力，以及IBM功能评定量表（IBMFRS）、改良Rankin评分、用力肺活量（FVC）和改良眼球面部呼吸量表（mOBFRS）。采用描述性统计和Pearson’s r相关对数据进行分析。患者的年龄与任何结果测量都无关。IBMFRS评分的严重程度越高，病程越长，FVC、强度结局、TGU、改良Rankin和mOBFRS的严重程度也越高。此外，TGU与肌肉力量测量、改良Rankin和mOBFRS密切相关。mOBFRS与IBMFRS、肌力、FVC、TGU、修正Rankin评分呈正相关。在这项研究中，我们证明了疾病严重程度结果测量之间的中度到强相关性。
This study aimed to evaluate the correlation between various outcome measures used to assess disease severity and progression in inclusion body myositis (IBM) clinical trials. A cross-sectional study, involving 51 IBM patients meeting the European Neuromuscular Center (ENMC) 2011 criteria for clinically defined or probable IBM, was completed at the University of California, Irvine. Clinical details, demographic data, and functional data including timed get up (TGU), manual muscle testing, hand grip, pinch dynamometry, as well as IBM functional rating scale (IBMFRS), modified Rankin score, forced vital capacity (FVC), and modified ocular bulbar facial respiratory scale (mOBFRS) were collected on all patients. Descriptive statistics and Pearson’s r correlation were performed to analyze the data. Age of the patient did not correlate with any of the outcome measures. Greater severity of IBMFRS scores correlated with longer disease duration as well as greater severity for FVC, strength outcomes, TGU, modified Rankin, and mOBFRS. Additionally, TGU strongly correlated with muscle strength measurements, modified Rankin, and mOBFRS. mOBFRS moderately correlated with IBMFRS, muscle strength, FVC, TGU and modified Rankin score. We demonstrate moderate to strong correlations among the disease severity outcome measures in this study.
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影响因子：
48
作者：
Hanna, Michael G.;Badrising, Umesh A.;Nishino, Ichizo
通讯作者：
Nishino, Ichizo
影响因子：
3.4
作者：
Farrugia, Maria E.;Harle, Heather D.;Burns, Ted M.
通讯作者：
Burns, Ted M.
DOI：
10.1212/con.0000000000000790
发表时间：
2019-12-01
期刊：
Continuum (Minneapolis, Minn.)
影响因子：
--
作者：
Weihl, Conrad C
通讯作者：
Weihl, Conrad C
影响因子：
2.8
作者：
Allenbach, Yves;Benveniste, Olivier;Hogrel, Jean-Yves
通讯作者：
Hogrel, Jean-Yves
影响因子：
9.9
作者：
Goyal, Namita A.;Coulis, Gerald;Villalta, S. Armando
通讯作者：
Villalta, S. Armando