11β-hydroxyandrostenedione returns to the steroid arena: biosynthesis, metabolism and function.
11β-hydroxyandrostenedione returns to the steroid arena: biosynthesis, metabolism and function.
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DOI：
10.3390/molecules181113228
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发表时间：
2013-10-25
期刊：
影响因子：
--
通讯作者：
Swart AC
中科院分区：
文献类型：
--
作者：
Bloem LM;Storbeck KH;Schloms L;Swart AC
11β-羟基雄烯二酮（11 OHA 4）的生物学意义在过去的六十年里一直困扰着研究人员。现在已知11 OHA 4在肾上腺类固醇生成途径的雄激素臂中生物合成，随后在体外被类固醇生成酶代谢，作为公认的和新的雄激素类固醇的前体。这些体外研究结果超出了肾上腺，表明11 OHA 4可以在类固醇反应性外周组织中代谢，肾上腺来源的雄激素前体代谢物也是如此。当考虑到LNCaP雄激素依赖性前列腺癌细胞中11 OHA 4的代谢产生雄激素类固醇代谢物时，其意义变得明显。因此，11 OHA 4可能不仅在前列腺而且在其他类固醇反应组织中代谢产生类固醇受体的配体。因此，11 OHA 4的未来研究可能将其描述为具有深远生理后果的重要类固醇。将介绍自1953年确定以来对11 OHA 4的研究概况，特别关注最近的工作，这些工作促进了我们对其生物学作用的理解，从而强调了其在健康和疾病中的相关性。
The biological significance of 11β-hydroxyandrostenedione (11OHA4) has eluded researchers for the past six decades. It is now known that 11OHA4 is biosynthesized in the androgen arm of the adrenal steroidogenesis pathway and subsequently metabolized by steroidogenic enzymes in vitro, serving as precursor to recognized and novel androgenic steroids. These in vitro findings extend beyond the adrenal, suggesting that 11OHA4 could be metabolized in steroid-responsive peripheral tissues, as is the case for androgen precursor metabolites of adrenal origin. The significance thereof becomes apparent when considering that the metabolism of 11OHA4 in LNCaP androgen dependent prostate cancer cells yields androgenic steroid metabolites. It is thus possible that 11OHA4 may be metabolized to yield ligands for steroid receptors in not only the prostate but also in other steroid-responsive tissues. Future investigations of 11OHA4 may therefore characterize it as a vital steroid with far-reaching physiological consequences. An overview of the research on 11OHA4 since its identification in 1953 will be presented, with specific focus on the most recent works that have advanced our understanding of its biological role, thereby underscoring its relevance in health and disease.
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DOI：
10.1016/j.beem.2008.01.008
发表时间：
2008-04-01
影响因子：
7.4
作者：
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影响因子：
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DOI：
10.1016/0022-4731(76)90128-x
发表时间：
1976-01-01
影响因子：
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