Indoor black carbon and biomarkers of systemic inflammation and endothelial activation in COPD patients.
Indoor black carbon and biomarkers of systemic inflammation and endothelial activation in COPD patients.
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DOI：
10.1016/j.envres.2018.05.010
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发表时间：
2018-08
影响因子：
8.3
通讯作者：
Koutrakis P
中科院分区：
文献类型：
--
作者：
Garshick E;Grady ST;Hart JE;Coull BA;Schwartz JD;Laden F;Moy ML;Koutrakis P
在慢性阻塞性肺疾病（COPD）患者中，将交通相关颗粒暴露与系统性影响联系起来的证据有限。评估室内黑碳（一种交通相关颗粒的示踪剂）与全身炎症和内皮细胞激活的血浆生物标志物之间的关系。在85名慢性阻塞性肺病患者家中，平均7.6天内通过细颗粒样品的反射率测量BC，一年最多可季节性测量4次。采样完成后，检测血浆c -反应蛋白（CRP）、白细胞介素-6 （IL-6）、可溶性血管粘附分子-1 （sVCAM-1）。排除当前吸烟者和有主要BC来源的家庭；因此，室内BC主要是浸润的室外BC的量度。每个参与者使用随机截距的混合效应回归模型来评估BC在不同时间（采血前1-9天）和多天样本中的效果。测量BC中位数为0.19 μg/m3（四分位数间，IQR=0.22 μg/m3）。调整季节、种族、年龄、BMI、心脏病、糖尿病、环境温度、相对湿度、最近感冒或类似疾病、抽血时间等因素后，BC与CRP呈正相关。影响最大的是前7天的BC平均值（每IQR CRP增加11.8%;95%CI = 1.8-22.9）。非他汀类药物使用者和糖尿病患者的效果最大。BC仅在非他汀类药物使用者中对IL-6有积极影响。与sVCAM-1无关联。这些结果表明室内BC与COPD患者全身性炎症生物标志物之间存在暴露-反应关系，在未使用他汀类药物的患者和糖尿病患者中存在更强的关系。
Evidence linking traffic-related particle exposure to systemic effects in chronic obstructive lung disease (COPD) patients is limited. Assess relationships between indoor black carbon (BC), a tracer of traffic-related particles, and plasma biomarkers of systemic inflammation and endothelial activation. BC was measured by reflectance in fine particle samples over a mean of 7.6 days in homes of 85 COPD patients up to 4 times seasonally over a year. After the completion of sampling, plasma C-reactive protein (CRP), interleukin-6 (IL-6), and soluble vascular adhesion molecule-1 (sVCAM-1) were measured. Current smokers and homes with major sources of BC were excluded; therefore, indoor BC was primarily a measure of infiltrated outdoor BC. Mixed effects regression models with a random intercept for each participant were used to assess BC effects at different times (1–9 days before phlebotomy) and in the multi-day sample. Measured median BC was 0.19 μg/m3 (interquartile range, IQR=0.22 μg/m3). Adjusting for season, race, age, BMI, heart disease, diabetes, ambient temperature, relative humidity, a recent cold or similar illness, and blood draw time, there was a positive relationship between BC and CRP. The largest effect size was for BC averaged over the previous seven days (11.8% increase in CRP per IQR; 95%CI = 1.8–22.9). Effects were greatest among non-statin users and persons with diabetes. There were positive effects of BC on IL-6 only in non-statin users. There were no associations with sVCAM-1. These results demonstrate exposure-response relationships between indoor BC with biomarkers of systemic inflammation in COPD patients, with stronger relationships in persons not using statins and with diabetes.
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DOI：
10.1097/ede.0b013e31824523f0
发表时间：
2012-03
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Bind MA;Baccarelli A;Zanobetti A;Tarantini L;Suh H;Vokonas P;Schwartz J
通讯作者：
Schwartz J
影响因子：
10.4
作者：
Alexeeff SE;Coull BA;Gryparis A;Suh H;Sparrow D;Vokonas PS;Schwartz J
通讯作者：
Schwartz J
影响因子：
10
作者：
Atkinson RW;Kang S;Anderson HR;Mills IC;Walton HA
通讯作者：
Walton HA
影响因子：
11.8
作者：
Grady ST;Koutrakis P;Hart JE;Coull BA;Schwartz J;Laden F;Zhang JJ;Gong J;Moy ML;Garshick E
通讯作者：
Garshick E
影响因子：
10.4
作者：
Delfino, Ralph J.;Staimer, Norbert;Sioutas, Constantinos
通讯作者：
Sioutas, Constantinos