Indoor black carbon of outdoor origin and oxidative stress biomarkers in patients with chronic obstructive pulmonary disease.
Indoor black carbon of outdoor origin and oxidative stress biomarkers in patients with chronic obstructive pulmonary disease.
复制标题
DOI：
10.1016/j.envint.2018.02.040
复制
发表时间：
2018-06
影响因子：
11.8
通讯作者：
Garshick E
中科院分区：
文献类型：
--
作者：
Grady ST;Koutrakis P;Hart JE;Coull BA;Schwartz J;Laden F;Zhang JJ;Gong J;Moy ML;Garshick E
我们评估了慢性阻塞性肺病 (COPD) 参与者的室内黑碳 (BC) 暴露与尿液氧化应激生物标志物 8-羟基-2′-脱氧鸟苷 (8-OHdG) 和丙二醛 (MDA) 之间的关系。八十二名参与者在一年内提供四次尿液样本之前完成了一周的家庭空气采样。每周室内和每日室外浓度用于估计室内每日滞后和移动平均值。没有报告家庭内的 BC 来源，因此室内水平密切代表室外 BC 渗透。使用每个参与者随机截距的混合效应回归模型来评估室内 BC 与 8-OHdG 和 MDA 之间的关系，并调整年龄、种族、BMI、糖尿病、心脏病、季节、尿液收集时间、尿肌酐以及室外湿度和温度。 BC 对 8-OHdG 和 MDA 具有积极影响，其中对 8-OHdG 尿液收集前一天影响最大（增加 6.9%；95% CI 0.9-13.3%，每四分位数范围：0.22 μg/m3），对 MDA 收集前 1 至 4 天影响最大（增加 8.3%；95% CI 0.03-17.3%，每个 IQR）。在调整与 BC 和 NO2 无关的 PM2.5 的模型中，结果相似（8-OHdG 增加 10.4%，95% CI：3.5-17.9；MDA 增加 8.1%，95% CI：-1.1-18.1）。肥胖参与者对 8-OHdG 的影响更大。我们发现 BC 暴露与 8-OHdG 和 MDA 之间呈正相关，其中与 8-OHdG 的相关性在肥胖参与者中更强。这些结果表明，接触低水平的交通相关污染会导致慢性阻塞性肺病患者出现脂质过氧化和氧化性 DNA 损伤。
We assessed relationships between indoor black carbon (BC) exposure and urinary oxidative stress biomarkers, 8-hydroxy-2′-deoxyguanosine (8-OHdG) and malondialdehyde (MDA), in participants with chronic obstructive pulmonary disease (COPD). Eighty-two participants completed in-home air sampling for one week prior to providing urine samples up to four times in a year. Weekly indoor and daily outdoor concentrations were used to estimate indoor daily lags and moving averages. There were no reported in-home BC sources, thus indoor levels closely represented outdoor BC infiltration. Mixed effects regression models with a random intercept for each participant were used to assess relationships between indoor BC and 8-OHdG and MDA, adjusting for age, race, BMI, diabetes, heart disease, season, time of urine collection, urine creatinine, and outdoor humidity and temperature. There were positive effects of BC on 8-OHdG and MDA, with the greatest effect the day before urine collection (6.9% increase; 95% CI 0.9-13.3%, per interquartile range: 0.22 μg/m3) for 8-OHdG and 1 to 4 days before collection (8.3% increase; 95% CI 0.03-17.3% per IQR) for MDA. Results were similar in models adjusting for PM2.5 not associated with BC and NO2 (10.4% increase, 95% CI: 3.5-17.9 for 8-OHdG; 8.1% increase, 95% CI: −1.1-18.1 for MDA). Effects on 8-OHdG were greater in obese participants. We found positive associations between BC exposure and 8-OHdG and MDA, in which associations with 8-OHdG were stronger in obese participants. These results suggest that exposure to low levels of traffic-related pollution results in lipid peroxidation and oxidative DNA damage in individuals with COPD.
登录
查看更多内容
影响因子：
--
作者：
Ayala A;Muñoz MF;Argüelles S
通讯作者：
Argüelles S
呼出气冷凝物和尿液中的丙二醛作为空气污染引起的氧化应激的生物标志物
DOI：
10.1038/jes.2012.127
发表时间：
2013-05
影响因子：
4.5
作者：
通讯作者：
--
影响因子：
4.9
作者：
Kelly, FJ
通讯作者：
Kelly, FJ
DOI：
10.1016/j.mrfmmm.2005.01.022
发表时间：
2005-07-01
影响因子：
2.3
作者：
Cooke, MS;Evans, MD;Olinski, R
通讯作者：
Olinski, R
影响因子：
10.4
作者：
Baja ES;Schwartz JD;Wellenius GA;Coull BA;Zanobetti A;Vokonas PS;Suh HH
通讯作者：
Suh HH