Lacunar Infarcts Rather than White Matter Hyperintensity as a Predictor of Future Higher Level Functional Decline: The Ohasama Study.
Lacunar Infarcts Rather than White Matter Hyperintensity as a Predictor of Future Higher Level Functional Decline: The Ohasama Study.
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腔隙性梗死而不是白质高信号作为未来高级功能衰退的预测因子：Ohasama 研究。
DOI：
10.1016/j.jstrokecerebrovasdis.2016.09.036
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Ohkubo T.
中科院分区：
文献类型：
--
作者：
Tsubota-Utsugi M;Satoh M;Tomita N;Hara A;Kondo T;Hosaka M;Saito S;Asayama K;Inoue R;Hirano M;Hosokawa A;Murakami K;Murakami T;Metoki H;Kikuya M;Izumi SI;Imai Y;Ohkubo T.
我们的目的是确定无症状脑血管病变，特点是腔隙性梗死和白色物质高信号，和未来的下降，在老年社区居住adultes.Materials和MethodsFor这项观察性研究，我们选择了个人从一般人口的Ohasama，日本农村社区。331名参与者在基线时没有功能下降，并且至少60岁，他们接受了脑磁共振成像，并回答了来自东京都老年学研究所能力指数的高级功能能力问卷。我们评估了沉默的脑血管病变与更高层次的功能能力下降之间的关系，在7年使用多元Logistic回归分析调整可能的混杂factors.ResultsDuring后续，22.1%的报告下降，在更高层次的功能能力。在调整了假定的混杂因素后，无症状脑血管病变（比值比[95%置信区间]，2.10 [1.05-4.21]）、腔隙性梗死（2.04 [1.05-3.95]）和白色高信号（2.02 [1.02-3.95]）与7年随访时功能下降的风险显著相关。在分量表分析中，特别是腔隙性脑梗死与未来智力活动下降的风险密切相关（3.16 [1.27-7.84]）。适当管理健康危险因素以预防无症状脑血管病变可能会预防老年人群更高水平的功能下降。
ObjectiveWe aimed to determine the associations between silent cerebrovascular lesions, characterized by lacunar infarcts and white matter hyperintensity, and future decline in higher level functional capacity in older community-dwelling adults.Materials and MethodsFor this observational study, we selected individuals from the general population of Ohasama, a rural Japanese community. Three hundred thirty-one participants who were free of functional decline at baseline and who were at least 60 years old underwent brain magnetic resonance imaging and answered a questionnaire on higher level functional capacity derived from the Tokyo Metropolitan Institute of Gerontology Index of Competence. Weassessed the relationship between silent cerebrovascular lesions with a decline in higher level functional capacity at 7 years using multiple logistic regression analysis adjusted for possible confounding factors.ResultsDuring the follow-up, 22.1% reported declines in higher level functional capacity. After adjustment for putative confounding factors, the presence of silent cerebrovascular lesions (odds ratio [95% confidence interval], 2.10 [1.05-4.21]) and both lacunar infarcts (2.04 [1.05-3.95]) and white matter hyperintensity (2.02 [1.02-3.95]) was significantly associated with the risk of functional decline at 7-year follow-up. In subscale analysis, specifically lacunar infarcts were strongly associated with the future risk of decline in intellectual activity (3.16 [1.27-7.84]).ConclusionSilent cerebrovascular lesions are associated with future risk of decline in higher level functional capacity. Appropriate management of health risk factors to prevent silent cerebrovascular lesions may prevent higher level functional decline in the elderly population.
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影响因子：
6.3
作者：
M. Tsubota;Rie Ito;T. Ohkubo;M. Kikuya;K. Asayama;H. Metoki;N. Fukushima;Ayumi Kurimoto;Y. Tsubono;Y. Imai
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DOI：
--
发表时间：
2003
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[日本老年人身体残疾的变化]。
DOI：
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发表时间：
1994
期刊：
[Nihon koshu eisei zasshi] Japanese journal of public health
影响因子：
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作者：
I. Tsuji;Y. Minami;A. Fukao;S. Hisamichi;M. Sato;H. Asano
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影响因子：
6
作者：
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影响因子：
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作者：
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通讯作者：
O'Brien, John T.