The development of cervical and vaginal adenosis as a result of diethylstilbestrol exposure in utero.
The development of cervical and vaginal adenosis as a result of diethylstilbestrol exposure in utero.
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DOI：
10.1016/j.diff.2012.05.004
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发表时间：
2012-10
期刊：
影响因子：
2.9
通讯作者：
Kurita, Takeshi
中科院分区：
文献类型：
--
作者：
Laronda, Monica M.;Unno, Kenji;Butler, Lindsey M.;Kurita, Takeshi
在发育过程中暴露于外源性激素会导致永久性的健康问题。子宫内暴露于己烯雌酚（DES）可能是人类历史上记录最充分的病例。DES是一种口服活性合成雌激素，被认为可以预防不良妊娠结果，因此从20世纪40年代到60年代，被常规地给予选定的孕妇。据估计，在此期间，全世界有500万孕妇服用了DES。在20世纪70年代早期，阴道透明细胞腺癌（CCACs）被诊断为母亲在怀孕期间服用DES的女儿（称为DES女儿）。后续研究表明，子宫内暴露于DES会导致女性生殖道和CCACs的一系列先天性异常。其中，宫颈和阴道腺最常见，被认为是CCACs的前体。转化相关蛋白63 （TRP63/p63）标志着子宫颈和阴道导管上皮（MDE）向鳞状上皮转变的细胞命运决定。DES破坏小鼠TRP63的表达，诱导子宫颈和阴道腺病病变。本文综述了可用于研究des诱导的异常发展的小鼠模型，重点是宫颈和阴道腺病，并讨论了其分子发病机制。
Exposure to exogenous hormones during development can result in permanent health problems. In utero exposure to diethylstilbestrol (DES) is probably the most well documented case in human history. DES, an orally active synthetic estrogen, was believed to prevent adverse pregnancy outcome and thus was routinely given to selected pregnant women from the 1940s to the 1960s. It has been estimated that 5 million pregnant women worldwide were prescribed with DES during this period. In the early 1970s, vaginal clear cell adenocarcinomas (CCACs) were diagnosed in daughters whose mother took DES during pregnancy (known as DES daughters). Follow up studies demonstrated that exposure to DES in utero causes a spectrum of congenital anomalies in female reproductive tracts and CCACs. Among those, cervical and vaginal adenoses are most commonly found, which are believed to be the precursors of CCACs. Transformation related protein 63 (TRP63/p63) marks the cell fate decision of Müllerian duct epithelium (MDE) to become squamous epithelium in the cervix and vagina. DES disrupts the TRP63 expression in mice and induces adenosis lesions in the cervix and vagina. This review describes mouse models can be used to study the development of DES-induced anomalies, focusing on cervical and vaginal adenoses, and discusses its molecular pathogenesis.
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影响因子：
3.6
作者：
Gendron, RL;Paradis, H;Markoff, E
通讯作者：
Markoff, E
DOI：
10.1098/rspb.1939.0015
发表时间：
1939-01-01
期刊：
PROC ROY SOC SET B BIOL SCI
影响因子：
--
作者：
DODDS, E. C.;GOLBERG, L.;ROBINSON, ROBERT
通讯作者：
ROBINSON, ROBERT
DOI：
10.1016/0002-9378(72)90456-5
发表时间：
1972-01-01
影响因子：
9.8
作者：
FORSBERG, JG
通讯作者：
FORSBERG, JG
DOI：
10.1016/0002-9378(70)90265-6
发表时间：
1970-01-01
影响因子：
9.8
作者：
HERBST, AL;GREEN, TH;ULFELDER, H
通讯作者：
ULFELDER, H
影响因子：
3.3
作者：
HALLING, A
通讯作者：
HALLING, A