Susceptibility to COVID-19 Diagnosis in People with Down Syndrome Compared to the General Population: Matched-Cohort Study Using Primary Care Electronic Records in the UK.
Susceptibility to COVID-19 Diagnosis in People with Down Syndrome Compared to the General Population: Matched-Cohort Study Using Primary Care Electronic Records in the UK.
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唐氏综合症患者与普通人群相比对 COVID-19 诊断的易感性：使用英国初级保健电子记录的匹配队列研究。
DOI：
10.1007/s11606-022-07420-9
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发表时间：
2022-06
影响因子：
5.7
通讯作者：
Gulliford MC
中科院分区：
文献类型：
--
作者：
Baksh RA;Strydom A;Pape SE;Chan LF;Gulliford MC
在COVID-19大流行期间，唐氏综合征（DS）患者经历了比普通人群更严重的病程和更高的死亡率。目前尚不清楚DS患者是否更容易被诊断为COVID-19。探索DS是否与COVID-19易感性增加相关。匹配队列研究设计，使用2021年5月发布的临床实践研究数据链（CPRD）Aurum的匿名初级保健电子健康记录。来自英格兰大约1400个全科医生（GP）的电子健康记录。在2020年1月29日或之后登记的8854名DS患者和34，724名对照者的年龄，性别和GP匹配。主要结局为2020年1月至2021年5月期间的COVID-19诊断。拟合条件逻辑回归模型来估计DS与COVID-19诊断之间的关联，并针对合并症进行调整。与对照组相比，DS患者更有可能被诊断为COVID-19（7.4% vs 5.6%，p ≤ 0.001，比值比（OR）= 1.35; 95% CI = 1.23-1.48）。DS患者与慢性呼吸道疾病诊断（不包括哮喘）之间存在显著的相互作用，并增加了COVID-19诊断的几率（OR = 1.71; 95% CI = 1.20-2.43），同时调整了一些合并症。DS患者感染COVID-19的风险增加。那些有潜在肺部疾病的人在病毒大流行期间特别脆弱，应该优先接种疫苗。
During the COVID-19 pandemic, people with Down syndrome (DS) have experienced a more severe disease course and higher mortality rates than the general population. It is not yet known whether people with DS are more susceptible to being diagnosed with COVID-19. To explore whether DS is associated with increased susceptibility to COVID-19. Matched-cohort study design using anonymised primary care electronic health records from the May 2021 release of Clinical Practice Research Datalink (CPRD) Aurum. Electronic health records from approximately 1400 general practices (GPs) in England. 8854 people with DS and 34,724 controls matched for age, gender and GP who were registered on or after the 29th January 2020. The primary outcome was COVID-19 diagnosis between January 2020 and May 2021. Conditional logistic regression models were fitted to estimate associations between DS and COVID-19 diagnosis, adjusting for comorbidities. Compared to controls, people with DS were more likely to be diagnosed with COVID-19 (7.4% vs 5.6%, p ≤ 0.001, odds ratio (OR) = 1.35; 95% CI = 1.23–1.48). There was a significant interaction between people with DS and a chronic respiratory disease diagnosis excluding asthma and increased odds of a COVID-19 diagnosis (OR = 1.71; 95% CI = 1.20–2.43), whilst adjusting for a number of comorbidities. Individuals with DS are at increased risk for contracting COVID-19. Those with underlying lung conditions are particularly vulnerable during viral pandemics and should be prioritised for vaccinations.
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影响因子：
1.7
作者：
Kanamori, G;Witter, M;Williams-Smith, L
通讯作者：
Williams-Smith, L
影响因子：
3.5
作者：
Illouz T;Biragyn A;Frenkel-Morgenstern M;Weissberg O;Gorohovski A;Merzon E;Green I;Iulita F;Flores-Aguilar L;Dierssen M;De Toma I;Lifshitz H;Antonarakis SE;Yu E;Herault Y;Potier MC;Botté A;Roper R;Sredni B;Sarid R;London J;Mobley W;Strydom A;Okun E
通讯作者：
Okun E
影响因子：
5.5
作者：
Cummings, P;McKnight, B;Greenland, S
通讯作者：
Greenland, S
影响因子：
5.1
作者：
Glasson, Emma J.;Jacques, Angela;Leonard, Helen
通讯作者：
Leonard, Helen
影响因子：
2.6
作者：
Jick, Susan S.;Hagberg, Katrina Wilcox;Myles, Puja
通讯作者：
Myles, Puja