At clinical high risk for psychosis: outcome for nonconverters.
At clinical high risk for psychosis: outcome for nonconverters.
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DOI：
10.1176/appi.ajp.2011.10081191
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发表时间：
2011-08
期刊：
影响因子：
--
通讯作者：
Heinssen R
中科院分区：
文献类型：
--
作者：
Addington J;Cornblatt BA;Cadenhead KS;Cannon TD;McGlashan TH;Perkins DO;Seidman LJ;Tsuang MT;Walker EF;Woods SW;Heinssen R
早期干预研究的一个主要焦点是确定转化为精神病的风险并开发最佳预测算法。尽管文献中报道的不转化率各不相同，但不转化率始终包括大多数（50%-85%）的样本参与者。对这组被称为假阳性个体的结果知之甚少。一项纵向研究对300多名符合精神病风险综合征标准的寻求治疗的个体进行了前瞻性鉴定。作为北美前驱期纵向研究的一部分，参与者被招募并在八个临床研究中心进行评估。在2.5年的随访评估期间，214名（71%）参与者没有转变为精神病。研究样本包括111个个体，他们至少有1年的随访数据，并且在研究期间没有转变为精神病。在第1年，对减轻的阳性和阴性症状的评分有显著改善。然而，43%的样本在1年后和41%的样本在2年后仍然存在至少一种减弱的阳性症状。在随访时间点上，临床样本的社会和角色功能明显较非精神病对照受试者差。符合前驱症状标准的寻求帮助的个体似乎代表了那些真正有精神病风险并且正在显示疾病的最初迹象的人，那些在用于指示临床高风险状态的症状方面有所缓解的人，以及那些继续具有减弱的阳性症状的人。
A major focus of early intervention research is determining the risk of conversion to psychosis and developing optimal algorithms of prediction. Although reported rates of nonconversion vary in the literature, the nonconversion rate always encompasses a majority (50%–85%) of the sample participants. Less is known about the outcome among this group, referred to as false positive individuals. A longitudinal study was conducted of more than 300 prospectively identified treatment-seeking individuals meeting criteria for a psychosis-risk syndrome. Participants were recruited and evaluated across eight clinical research centers as part of the North American Prodrome Longitudinal Study. Over a 2.5-year follow-up assessment period, 214 (71%) participants had not made the transition to psychosis. The sample examined included 111 individuals who had at least 1 year of follow-up data available and did not transition to psychosis within the study duration. In year 1, there was significant improvement in ratings for attenuated positive and negative symptoms. However, at least one attenuated positive symptom was still present for 43% of the sample at 1 year and for 41% at 2 years. At the follow-up timepoints, social and role functioning were significantly poorer in the clinical sample relative to nonpsychiatric comparison subjects. Help-seeking individuals who meet prodromal criteria appear to represent those who are truly at risk for psychosis and are showing the first signs of illness, those who remit in terms of the symptoms used to index clinical high-risk status, and those who continue to have attenuated positive symptoms.
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影响因子：
6.6
作者：
Woods, Scott W.;Addington, Jean;McGlashan, Thomas H.
通讯作者：
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影响因子：
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作者：
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DOI：
10.3109/00048679609062654
发表时间：
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影响因子：
4.6
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
--
作者：
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通讯作者：
Klosterkoetter, Joachim