Gadolinium-based contrast agents for magnetic resonance cancer imaging.
Gadolinium-based contrast agents for magnetic resonance cancer imaging.
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DOI：
10.1002/wnan.1198
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发表时间：
2013-01
影响因子：
8.6
通讯作者：
Lu, Zheng-Rong
中科院分区：
文献类型：
--
作者：
Zhou, Zhuxian;Lu, Zheng-Rong
磁共振成像（MRI）是一种对包括实体瘤在内的病变软组织进行解剖和功能成像的有效临床成像方式。MRI造影剂已被常规用于早期检测肿瘤。钆基造影剂是临床MRI中最常用的造影剂。设计和开发具有高松弛性、低毒性和特异性肿瘤结合的新型Gd（III）造影剂已经付出了巨大的努力。通过适当的化学改性可以提高Gd（III）造影剂的弛豫度。通过提高Gd（III）造影剂的热力学和动力学稳定性，以及优化其药动学性质，可以降低Gd（III）造影剂的毒性。在癌症基因组学和生物学领域不断增长的知识为设计肿瘤特异性造影剂提供了机会。各种新的Gd（III）螯合剂已经设计并在动物模型中进行了评估，以获得更有效的癌症MRI。本文综述了几种Gd（III）基MR造影剂的设计和开发、物理化学特性和体内特性。
Magnetic resonance imaging (MRI) is a clinical imaging modality effective for anatomical and functional imaging of diseased soft tissues, including solid tumors. MRI contrast agents have been routinely used for detecting tumor at an early stage. Gadolinium based contrast agents are the most commonly used contrast agents in clinical MRI. There have been significant efforts to design and develop novel Gd(III) contrast agents with high relaxivity, low toxicity and specific tumor binding. The relaxivity of the Gd(III) contrast agents can be increased by proper chemical modification. The toxicity of Gd(III) contrast agents can be reduced by increasing the agents’ thermodynamic and kinetic stability, as well as optimizing their pharmacokinetic properties. The increasing knowledge in the field of cancer genomics and biology provides an opportunity for designing tumor-specific contrast agents. Various new Gd(III) chelates have been designed and evaluated in animal models for more effective cancer MRI. This review outlines the design and development, physicochemical properties, and in vivo properties of several classes of Gd(III)-based MR contrast agents for tumor imaging.
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DOI：
10.1002/jmri.1880040336
发表时间：
1994-05-01
期刊：
JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING
影响因子：
--
作者：
ADAM, G;NEUERBURG, J;GUNTHER, RW
通讯作者：
GUNTHER, RW
影响因子：
6.7
作者：
BAXTER, AB;MELNIKOFF, S;BRASCH, RC
通讯作者：
BRASCH, RC
DOI：
10.1002/jmri.1880040337
发表时间：
1994-05-01
期刊：
JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING
影响因子：
--
作者：
DESSER, TS;RUBIN, DL;SNOW, RA
通讯作者：
SNOW, RA
肽缀合聚酰胺胺树状聚合物作为纳米级肿瘤靶向 T1 磁共振成像造影剂
影响因子：
14
作者：
Han, Liang;Li, Jianfeng;Jiang, Chen
通讯作者：
Jiang, Chen
DOI：
10.1016/j.ejpb.2008.09.017
发表时间：
2009-06-01
影响因子：
4.9
作者：
Hak, Sjoerd;Sanders, Honorius M. H. F.;Nicolay, Klaas
通讯作者：
Nicolay, Klaas