A Review: The Manifestations, Mechanisms, and Treatments of Musculoskeletal Pain in Patients With COVID-19.
A Review: The Manifestations, Mechanisms, and Treatments of Musculoskeletal Pain in Patients With COVID-19.
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综述：COVID-19 患者肌肉骨骼疼痛的表现、机制和治疗
DOI：
10.3389/fpain.2022.826160
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Su C
中科院分区：
文献类型：
--
作者：
Wang L;Yang N;Yang J;Zhao S;Su C
COVID-19的爆发对全球健康构成严重威胁。肌肉骨骼（MSK）疼痛是COVID-19患者除发热和咳嗽外最常见的症状。针对COVID-19患者的MSK症状的研究有限。本文综述了当前与COVID-19患者MSK疼痛相关的研究，总结了肌痛的可能机制，并描述了当前的管理方案。除了急性呼吸道症状外，COVID-19还可能影响神经系统，包括骨骼症状和肌肉损伤。COVID-19中MSK疼痛和肌痛的可能机制可能与血管紧张素转换酶2（ACE-2）的分布和细胞因子风暴的发生有关。ACE-2已被证明是严重急性呼吸道综合征冠状病毒2（SARS-COV 2）的受体。此外，研究表明，炎性细胞因子可通过诱导前列腺素E2（PGE 2）的产生引起肌痛。此外，还发现COVID-19患者的IL-2、IL-7、IL-10、IL-6、TNFα和e淋巴细胞减少症的血浆水平较高。一般而言，COVID-19福尔斯患者MSK疼痛的治疗分为药物和非药物干预。各种治疗方法各有千秋。疫苗接种在预防COVID-19及减轻其后续症状方面的作用不可替代。
The outbreak of COVID-19 poses a serious threat to global health. Musculoskeletal (MSK) pain is the most frequent symptom in patients with COVID-19 besides fever and cough. There are limited studies addressing MSK symptoms in patients with COVID-19. This review aims to provide an overview of current studies related to MSK pain in patients with COVID-19, summarize the possible mechanisms of myalgia, and describe the current management options. In addition to acute respiratory manifestations, COVID-19 might also affect neurological systems which include skeletal manifestations and muscular injury. A possible mechanism of MSK pain and myalgia in COVID-19 may be related to the distribution of angiotensin-converting enzyme 2 (ACE-2) and the occurrence of cytokine storms. ACE-2 has been shown to be the receptor of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV2). Moreover, studies have shown that inflammatory cytokines could cause myalgia by inducing prostaglandin E2 (PGE2) production. In addition, it was also found that the plasma levels of IL2, IL7, IL10, IL-6, TNFα, and e lymphopenia were higher in patients with COVID-19. In general, the treatment of MSK pain in patients with COVID-19 falls into pharmacological and non-pharmacological interventions. Various treatments of each have its own merits. The role of vaccination is irreplaceable in the efforts to prevent COVID-19 and mitigates its subsequent symptoms.
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影响因子：
158.5
作者：
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影响因子：
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通讯作者：
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