Clinicopathologic features and outcomes following surgery for pancreatic adenosquamous carcinoma.
Clinicopathologic features and outcomes following surgery for pancreatic adenosquamous carcinoma.
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DOI：
10.1186/1477-7819-6-95
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发表时间：
2008-09-03
影响因子：
3.2
通讯作者：
Chen MF
中科院分区：
文献类型：
--
作者：
Hsu JT;Chen HM;Wu RC;Yeh CN;Yeh TS;Hwang TL;Jan YY;Chen MF
胰腺腺鳞癌（ASC）是一种罕见的胰腺恶性肿瘤亚型。我们调查了胰腺 ASC 患者术后的临床病理特征和结果。回顾性分析1993年至2006年期间接受手术治疗的12例胰腺ASC患者的病历。比较了接受手术切除的 IIB 期胰腺腺癌和 ASC 患者的生存数据。症状包括腹痛（91.7%）、体重减轻（83.3%）、厌食（41.7%）和黄疸（25.0%）。肿瘤位于胰头部 5 例（41.7%），尾部 5 例（41.7%），体部 4 例（33.3%）。肿瘤大小中位数为 6.3 厘米。 7 名患者接受了手术切除，3 名患者接受了搭桥手术，2 名患者接受了剖腹探查并进行活检。未发现手术死亡。术后 6 个月和 12 个月内分别有 7 例（58.3%）和 11 例（91.7%）患者死亡。 12名患者的中位生存期为4.41个月。 7 名接受手术切除的患者的中位生存期为 6.51 个月。与腺癌患者相比，IIB 期胰腺 ASC 患者的中位生存期较短。积极的手术治疗似乎对治疗胰腺 ASC 患者无效。应测试涉及非手术治疗的策略，例如化疗、放疗或靶向药物。
Pancreatic adenosquamous carcinoma (ASC) is a rare pancreatic malignancy subtype. We investigated the clinicopathological features and outcome of pancreatic ASC patients after surgery. The medical records of 12 patients with pancreatic ASC undergoing surgical treatment (1993 to 2006) were retrospectively reviewed. Survival data of patients with stage IIB pancreatic adenocarcinoma and ASC undergoing surgical resection were compared. Symptoms included abdominal pain (91.7%), body weight loss (83.3%), anorexia (41.7%) and jaundice (25.0%). Tumors were located at pancreatic head in 5 (41.7%) patients, tail in 5 (41.7%), and body in 4 (33.3%). Median tumor size was 6.3 cm. Surgical resection was performed on 7 patients, bypass surgery on 3, and exploratory laparotomy with biopsy on 2. No surgical mortality was identified. Seven (58.3%) and 11 (91.7%) patients died within 6 and 12 months of operation, respectively. Median survival of 12 patients was 4.41 months. Seven patients receiving surgical resection had median survival of 6.51 months. Patients with stage IIB pancreatic ASC had shorter median survival compared to those with adenocarcinoma. Aggressive surgical management does not appear effective in treating pancreatic ASC patients. Strategies involving non-surgical treatment such as chemotherapy, radiotherapy or target agents should be tested.
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影响因子：
7.5
作者：
Kardon, DE;Thompson, LDR;Heffess, CS
通讯作者：
Heffess, CS
影响因子：
2.5
作者：
YAMAGUCHI, K;ENJOJI, M
通讯作者：
ENJOJI, M
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3.9
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ALDOROUBI, QI;PETRELLI, M;REID, JD
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REID, JD
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9
作者：
Yeo, CJ;Cameron, JL;Abrams, RA
通讯作者：
Abrams, RA
影响因子：
2.5
作者：
MOTOJIMA, K;TOMIOKA, T;KANEMATSU, T
通讯作者：
KANEMATSU, T