Sex-specific associations between lipids and cognitive decline in the middle-aged and elderly: a cohort study of Chinese adults.
Sex-specific associations between lipids and cognitive decline in the middle-aged and elderly: a cohort study of Chinese adults.
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中老年人血脂与认知能力下降之间的性别相关性：中国成年人的队列研究
DOI：
10.1186/s13195-020-00731-1
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发表时间：
2020-12-07
期刊：
影响因子：
--
通讯作者：
Zhan S
中科院分区：
文献类型：
--
作者：
Liu L;Zhang C;Lv X;Lai X;Xu L;Feng J;Song Y;Wang S;Zhan S
关于脂质-认知关系的研究越来越受欢迎，但产生了许多不同的结果。迄今为止，很少有研究关注性别之间的差异。方法本研究纳入6792名年龄在45岁以上的中国成年人（女性48.56%，平均年龄57.28岁），在基线时无已知影响认知功能的严重疾病（2011年）。在基线时评估血液中总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-c）、低密度脂蛋白胆固醇（LDL-c）和甘油三酯（TG）的浓度，并在最终分析中使用连续值和分类值。分别于2011年、2013年和2015年通过单词回忆测试和精神状态测试评估受试者的整体认知功能。我们根据认知变化斜率将参与者分为三组：无下降（≥0），中度下降（中位数至0）和严重下降（<中位数）。使用有序逻辑模型，调整社会人口统计信息、生活方式行为和健康状况，分析了血脂和认知能力下降之间的性别特异性关联。结果较高的基线TC和LDL-C浓度与男性5年认知能力下降无显著相关性，但与女性5年认知能力下降显著相关[优势比（OR） 1.026, 95%可信区间（CI） 1.003, 1.050；OR 1.026, CI 1.002, 1.051]。对于较高的血清HDL-c水平，在男性中观察到显著的认知保护作用，但在女性中发现轻微的不利影响（经Bonferroni校正后不显着）。甘油三酯对两性的后期认知几乎没有影响。结论血脂与认知的关系存在性别差异，维持血清胆固醇水平在适当范围内可能对认知健康有积极作用。
BackgroundStudies regarding the lipid-cognition relationship have increasingly gained popularity but have generated much mixed results. To date, few studies have focused on the difference between sexes.MethodsThis study included 6792 Chinese adults aged over 45 years (women, 48.56%; mean age, 57.28 years), who were free of severe conditions known to affect cognitive function at the baseline (2011). Blood concentrations of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), and triglycerides (TG) were assessed at baseline, and both continuous and categorical values were used in final analyses. Global cognitive functions were assessed by the word recall test and the mental status test in 2011, 2013, and 2015, respectively. We graded participants into three groups according to the cognitive change slopes: no decline (≥ 0), moderate decline (median to 0), and severe decline (< median). Sex-specific associations between blood lipids and cognitive decline were analyzed using ordinal logistic models, adjusting for sociodemographic information, lifestyle behaviors, and health status.ResultsHigher baseline TC and LDL-C concentrations exhibited no significant association with 5-year cognitive decline in men but were significantly associated with greater 5-year cognitive decline in women [odds ratio (OR) 1.026, 95% confidence interval (CI) 1.003, 1.050; OR 1.026, CI 1.002, 1.051, respectively]. For higher serum HDL-c levels, a significantly protective effect on cognition was observed in men, but a slightly adverse effect was found in women (not significant after Bonferroni correction). TG presented almost no effect on later cognition in either sex.ConclusionDifferent associations between sexes were observed for the lipid-cognition relationship, and maintaining serum cholesterol levels at an appropriate range may have a positive effect on cognitive health.
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DOI：
10.1016/j.jalz.2017.11.002
发表时间：
2018-05
期刊：
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影响因子：
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