Binocular visual experience drives the maturation of response variability and reliability in the visual cortex.
Binocular visual experience drives the maturation of response variability and reliability in the visual cortex.
复制标题
双眼视觉体验推动视觉皮层反应变异性和可靠性的成熟
DOI：
10.1016/j.isci.2022.104984
复制
发表时间：
2022-09-16
期刊：
影响因子：
5.8
通讯作者：
Gu, Yu
中科院分区：
文献类型：
--
作者：
Hao, Xiangwen;Liu, Qiong;Chan, Jiangping;Li, Na;Shi, Xuefeng;Gu, Yu
神经科学的一个基本挑战是了解单个神经元如何有效和可靠地响应多个突触输入。在初级视觉皮层，对一只眼睛的重复刺激引起固有的可变性和可靠性的神经元反应。然而，目前还不清楚这种单眼的可变性和可靠性如何有助于建立有效和可靠的双眼反应，以及是什么推动了这种发展。在这项研究中，使用在体多通道细胞外记录，我们证明了成年小鼠视觉皮层的双眼反应表现出低变异性和高可靠性。在双眼视觉发育的关键时期，这种反应特征是不成熟的。在弱视小鼠中，双眼可变性和可靠性的成熟被破坏，这种缺陷可以通过黑暗暴露增强皮质可塑性来部分挽救。总之，皮层反应的可变性和可靠性的发展取决于正常的双眼视觉经验，这是进一步调节皮层可塑性。反应可靠性是由成熟的皮层网络驱动的双眼输入的整合促进了高可靠性的成熟需要正常的视觉体验黑暗暴露可以部分恢复受损的皮层可靠性生物科学;发育生物学;生理学;感觉神经科学
A fundamental challenge of neuroscience is to understand how a single neuron responds to multiple synaptic inputs effectively and reliably. In primary visual cortex, repeated stimuli to one eye elicit neuronal responses of inherent variability and reliability. However, it remains unclear how this monocular variability and reliability contribute to the establishment of effective and reliable binocular responses and what drives this development. In this study, using in vivo multichannel extracellular recordings, we demonstrate binocular responses in adult mouse visual cortex exhibit low variability and high reliability. This response characteristic is immature during the critical period of binocular vision development. In amblyopic mice, the maturation of binocular variability and reliability is disrupted, and this defect can be partially rescued by enhancing cortical plasticity via dark exposure. In conclusion, the development of cortical response variability and reliability depends on the normal binocular visual experience, which is further regulated by cortical plasticity. The response reliability was driven by the mature cortical network Integration of binocular inputs facilitated the high reliability Normal visual experience is required for the maturation of reliability Dark exposure can partly restore the disrupted cortical reliability Biological sciences; Developmental biology; Physiology; Sensory neuroscience
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DOI：
10.1016/j.cub.2020.09.067
发表时间：
2020-12-21
期刊：
Current biology : CB
影响因子：
--
作者：
Jacobs EAK;Steinmetz NA;Peters AJ;Carandini M;Harris KD
通讯作者：
Harris KD
通过黑暗暴露增强视觉皮层可塑性。
DOI：
10.1098/rstb.2016.0159
发表时间：
2017-03-05
期刊：
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
影响因子：
--
作者：
Erchova I;Vasalauskaite A;Longo V;Sengpiel F
通讯作者：
Sengpiel F
影响因子：
25
作者：
Goris, Robbe L. T.;Movshon, J. Anthony;Simoncelli, Eero P.
通讯作者：
Simoncelli, Eero P.
影响因子：
16.2
作者：
Ecker AS;Berens P;Cotton RJ;Subramaniyan M;Denfield GH;Cadwell CR;Smirnakis SM;Bethge M;Tolias AS
通讯作者：
Tolias AS
DOI：
10.1016/j.cub.2017.03.074
发表时间：
2017-05-22
期刊：
Current biology : CB
影响因子：
--
作者：
Goncalves NR;Welchman AE
通讯作者：
Welchman AE