Cortical State Fluctuations during Sensory Decision Making.
Cortical State Fluctuations during Sensory Decision Making.
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DOI：
10.1016/j.cub.2020.09.067
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发表时间：
2020-12-21
期刊：
影响因子：
--
通讯作者：
Harris KD
中科院分区：
文献类型：
--
作者：
Jacobs EAK;Steinmetz NA;Peters AJ;Carandini M;Harris KD
在许多行为任务中，皮层进入一种去激活状态，在这种状态下，群体活动的低频波动被抑制。去殖民化及其全球组织的精确行为相关性尚不清楚。一种假说认为，去刺激增强了相关感觉皮层中的刺激编码。另一种假设认为，去兴奋化反映了整体唤醒，如任务参与。在这里，我们训练小鼠完成任务，其中任务参与可以与感官准确性区分开来。使用宽场钙成像，我们发现，性能相关的去钙化是全球性的，与参与度的相关性比与准确性的相关性更好。与这种去职业化和参与之间的联系相一致，奖励具有持久的去职业化效果。为了确定与记忆相关的状态变化是否取决于相关的感觉方式，我们对小鼠进行了视觉和听觉任务的训练，发现在这两种情况下，去记忆化都是全局性的，包括躯体运动皮层等区域。我们的结论是，低频波动的变化主要是全球性的，并与任务的参与。皮质3- 6 Hz波动与参与度的相关性大于表现3- 6 Hz振荡是全局性的，不依赖于任务的感觉模态。测试缓慢（3-6 Hz）皮层振荡在感觉引导的决策任务中损害表现的假设。他们发现，缓慢振荡与参与度的关系比与表现的关系更大：在缓慢振荡增加的情况下，小鼠不太可能做出反应，但也不太可能做出错误的反应。
In many behavioral tasks, cortex enters a desynchronized state where low-frequency fluctuations in population activity are suppressed. The precise behavioral correlates of desynchronization and its global organization are unclear. One hypothesis holds that desynchronization enhances stimulus coding in the relevant sensory cortex. Another hypothesis holds that desynchronization reflects global arousal, such as task engagement. Here, we trained mice on tasks where task engagement could be distinguished from sensory accuracy. Using widefield calcium imaging, we found that performance-related desynchronization was global and correlated better with engagement than with accuracy. Consistent with this link between desynchronization and engagement, rewards had a long-lasting desynchronizing effect. To determine whether engagement-related state changes depended on the relevant sensory modality, we trained mice on visual and auditory tasks and found that in both cases desynchronization was global, including regions such as somatomotor cortex. We conclude that variations in low-frequency fluctuations are predominately global and related to task engagement. Cortical 3- to 6-Hz fluctuations are more correlated with engagement than performance 3- to 6-Hz oscillations are global and do not depend on the sensory modality of the task Reduced slow oscillations may enable rapid, coordinated responses to sensory stimuli Jacobs et al. test the hypothesis that slow (3–6 Hz) cortical oscillations impair performance during sensory-guided decision-making tasks. They find that slow oscillations are more related to engagement than performance: mice are less likely to respond at all during increased slow oscillations, but no more likely to give an incorrect response.
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影响因子：
8.8
作者：
Burgess CP;Lak A;Steinmetz NA;Zatka-Haas P;Bai Reddy C;Jacobs EAK;Linden JF;Paton JJ;Ranson A;Schröder S;Soares S;Wells MJ;Wool LE;Harris KD;Carandini M
通讯作者：
Carandini M
细胞外田地和电流的起源-EEG，ECOG，LFP和尖峰。
DOI：
10.1038/nrn3241
发表时间：
2012-05-18
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Buzsáki G;Anastassiou CA;Koch C
通讯作者：
Koch C
影响因子：
16.2
作者：
Bosman CA;Schoffelen JM;Brunet N;Oostenveld R;Bastos AM;Womelsdorf T;Rubehn B;Stieglitz T;De Weerd P;Fries P
通讯作者：
Fries P
DOI：
10.1073/pnas.94.23.12699
发表时间：
1997-11-11
影响因子：
11.1
作者：
Fries, P;Roelfsema, PR;Singer, W
通讯作者：
Singer, W
影响因子：
--
作者：
Berger, H
通讯作者：
Berger, H