Oxytocin is implicated in social memory deficits induced by early sensory deprivation in mice.
Oxytocin is implicated in social memory deficits induced by early sensory deprivation in mice.
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催产素与早期感觉剥夺引起的小鼠社会记忆缺陷有关
DOI：
10.1186/s13041-016-0278-3
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发表时间：
2016-12-13
期刊：
影响因子：
3.6
通讯作者：
Ding YQ
中科院分区：
文献类型：
--
作者：
Zhang JB;Chen L;Lv ZM;Niu XY;Shao CC;Zhang C;Pruski M;Huang Y;Qi CC;Song NN;Lang B;Ding YQ
早期感觉输入在大脑发育中起着至关重要的作用。尽管在围产期剥夺口面部感觉输入会扰乱桶状皮质和相关胼胝体连接的建立，但它对成年人行为的长期影响仍然难以捉摸。在这项研究中，我们研究了出生后第3天(P3)一侧眶下神经(ION)切断的成年小鼠的行为表型。尽管离子切断小鼠具有正常的运动活动、运动协调、嗅觉、类焦虑行为、新的物体记忆、偏爱社会新颖性和社会性，但与对照小鼠相比，它们在社会记忆和空间记忆方面存在缺陷。此外，社会记忆缺陷与下丘脑中催产素(OXT)水平降低有关，并可通过鼻内注射OXT部分恢复。因此，早期感觉剥夺确实会导致小鼠的行为改变，其中一些可能与催产素信号的中断有关。
Early-life sensory input plays a crucial role in brain development. Although deprivation of orofacial sensory input at perinatal stages disrupts the establishment of the barrel cortex and relevant callosal connections, its long-term effect on adult behavior remains elusive. In this study, we investigated the behavioral phenotypes in adult mice with unilateral transection of the infraorbital nerve (ION) at postnatal day 3 (P3). Although ION-transected mice had normal locomotor activity, motor coordination, olfaction, anxiety-like behaviors, novel object memory, preference for social novelty and sociability, they presented deficits in social memory and spatial memory compared with control mice. In addition, the social memory deficit was associated with reduced oxytocin (OXT) levels in the hypothalamus and could be partially restored by intranasal administration of OXT. Thus, early sensory deprivation does result in behavioral alterations in mice, some of which may be associated with the disruption of oxytocin signaling.
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影响因子：
16.2
作者：
Insel, Thomas R.
通讯作者：
Insel, Thomas R.
影响因子：
10.6
作者：
Guastella, Adam J.;Einfeld, Stewart L.;Hickie, Ian B.
通讯作者：
Hickie, Ian B.
影响因子：
2.5
作者：
DURHAM, D;WOOLSEY, TA
通讯作者：
WOOLSEY, TA
体感皮层的胼胝体轴突定位需要感觉输入
影响因子：
3.6
作者：
Huang Y;Song NN;Lan W;Zhang Q;Zhang L;Zhang L;Hu L;Chen JY;Zhao CJ;Li L;Xu L;Ding YQ
通讯作者：
Ding YQ
影响因子：
5.3
作者：
Bender, KJ;Allen, CB;Feldman, DE
通讯作者：
Feldman, DE