Depression, anxiety disorders, and metabolic syndrome in a population at risk for type 2 diabetes mellitus.
Depression, anxiety disorders, and metabolic syndrome in a population at risk for type 2 diabetes mellitus.
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DOI：
10.1002/brb3.306
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发表时间：
2015-03
影响因子：
3.1
通讯作者：
Schwarz, Peter
中科院分区：
文献类型：
--
作者：
Kahl, Kai G.;Schweiger, Ulrich;Correll, Christoph;Mueller, Conrad;Busch, Marie-Luise;Bauer, Michael;Schwarz, Peter
关键词：
抑郁症状与2型糖尿病（T2 DM）有关，但对焦虑症可能共病或不伴抑郁的焦虑症知之甚少。我们评估了在门诊连续检查的糖尿病预防受试者中精神疾病的患病率，这些受试者有患2型糖尿病的风险，由FINDRISK评分定义，并比较了有和没有精神疾病的受试者之间代谢综合征（MetS）的频率，还将MetS的相关变量输入多变量分析。所有受试者均接受口服葡萄糖耐量试验（OGTT）。精神病诊断是使用DSM-IV的结构化临床访谈确认的。在260例连续筛选的受试者中，150例（56.9 ± 8.1岁，男性= 56.7%，BMI = 27.2 ± 4.1 kg/m2）有T2 DM风险，因此入选。MetS，存在于27%的男性和25%的女性中，与目前的焦虑症（P < 0.001）和终身抑郁症（P < 0.001）显著相关。在逻辑回归分析中，代谢综合征与终生抑郁症、任何焦虑症、体重和体力活动显著相关。我们在T2 DM高危人群中的数据支持抑郁症和代谢综合征之间的关联，指出焦虑症的作用类似。建议在有T2 DM风险的人群中进行焦虑和抑郁筛查。
Depressive symptoms have been associated with type 2 diabetes mellitus (T2DM), but less is known about anxiety disorders that can be comorbid or exist without depression. We evaluated the prevalence of psychiatric disorders in subjects consecutively examined at an outpatient clinic for diabetes prevention who were at-risk for T2DM, defined by FINDRISK scores, and compared metabolic syndrome (MetS) frequencies between subjects with and without psychiatric morbidity, entering also relevant variables for MetS into multivariate analyses. All subjects underwent an oral glucose tolerance test (OGTT). Psychiatric diagnosis was confirmed using a Structured Clinical Interview for DSM-IV. Of 260 consecutively screened subjects, 150 (56.9 ± 8.1 years old, males = 56.7%, BMI = 27.2 ± 4.1 kg/m2) were at-risk for T2DM and were included. MetS, present in 27% of males and 25% of females, was significantly associated with having a current anxiety disorder (P < 0.001) and lifetime major depression (P < 0.001). In logistic regression analysis, MetS was significantly associated with lifetime major depression, presence of any anxiety disorder, body weight, and physical activity. Our data in a high-risk group for T2DM support the association between depressive disorders and MetS, pointing to a similar role of anxiety disorders. Screening for anxiety and depression is recommended in this group at risk for T2DM.
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影响因子：
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作者：
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通讯作者：
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