Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression.
Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression.
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DOI：
10.1016/j.cmet.2009.10.003
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发表时间：
2009-11
期刊：
影响因子：
29
通讯作者：
Kenyon C
中科院分区：
文献类型：
--
作者：
Lee SJ;Murphy CT;Kenyon C
许多研究已经探讨了饮食血糖指数对肥胖和糖尿病的影响，但对其对寿命本身的影响知之甚少。我们发现在培养基中添加少量葡萄糖（0.1-2%）可缩短秀丽隐杆线虫的寿命。葡萄糖通过抑制寿命延长转录因子的活动而缩短寿命，这些转录因子也被胰岛素信号抑制：FOXO家族成员DAF-16和热休克因子HSF-1。这种效应涉及到水通道蛋白甘油通道aqp-1的下调。我们发现甘油代谢的变化可能是葡萄糖缩短寿命效应的基础，aqp-1可能在胰岛素/IGF-1信号通路中作为细胞非自主的反馈调节因子。在哺乳动物中，胰岛素下调了类似的甘油通道，这表明这种葡萄糖反应途径可能在进化上是保守的。总之，这些发现提出了一种可能性，即低糖饮食可能对高等生物的寿命有有益的影响。
Many studies have addressed the effect of dietary glycemic index on obesity and diabetes, but little is known about its effect on lifespan itself. We found that adding a small amount of glucose to the medium (0.1-2%) shortened the lifespan of C. elegans. Glucose shortened lifespan by inhibiting the activities of lifespan-extending transcription factors that are also inhibited by insulin signaling: the FOXO family member DAF-16 and the heat shock factor HSF-1. This effect involved the down-regulation of an aquaporin glycerol channel, aqp-1. We show that changes in glycerol metabolism are likely to underlie the lifespan-shortening effect of glucose, and that aqp-1 may act cell non-autonomously as a feedback regulator in the insulin/IGF-1 signaling pathway. Insulin down-regulates similar glycerol channels in mammals, suggesting that this glucose-responsive pathway might be conserved evolutionarily. Together these findings raise the possibility that a low-sugar diet might have beneficial effects on lifespan in higher organisms.
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