Mitochondrial DNA phylogeography of the Norway rat.
Mitochondrial DNA phylogeography of the Norway rat.
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DOI：
10.1371/journal.pone.0088425
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Kohn MH
中科院分区：
文献类型：
--
作者：
Song Y;Lan Z;Kohn MH
中亚，首先是与中国北部和蒙古接壤的地区，一直被认为是挪威老鼠(Rattus Norveicus)的发源地。然而，最近的化石分析表明，它们起源于中国南部。此外，尽管对化石的分析表明该物种的起源为120万-160万年前(Mya)，但分子分析得出的∼为0.5Mya-2.9Mya。在这里，为了研究挪威鼠的地理起源及其在全球的传播，我们分析了新发表的和所有已发表的代表四大洲野生鼠的线粒体细胞色素b(Cyt-b；N = 156)和D-LOOP(N = 212)序列，并选择了近交系。我们的结果与挪威鼠的起源是一致的，挪威鼠起源于中国南部的∼1.3Mya，随后在史前分化并从最初结构薄弱的祖先种群传播到中国和亚洲，然后在历史时期进一步在全球范围内传播和分化。最近的传播主要来自欧洲人，而不是古老的亚洲人。我们将实验室菌株追溯到来自欧洲和北美的野生血统，这些血统代表了老鼠多样性的一个子集；亚洲血统基本上没有被用作生物医学模型的资源。通过对来自欧洲的老鼠的研究，我们观察到，如果不考虑害虫控制，以及可能是杀鼠剂耐药性的进化，就不能解释线粒体DNA多样性。然而，通过远期模拟探索的人口统计模型不能完全解释欧洲大鼠线粒体DNA多样性较低，以及缺乏与亚洲来源的单倍型共享。需要对代表世界的更大样本的挪威鼠进行全面的核标记分析，以更好地了解野生鼠和实验室鼠的进化史，以及更好地了解抗凝剂耐药性的进化。
Central Eastern Asia, foremost the area bordering northern China and Mongolia, has been thought to be the geographic region where Norway rats (Rattus norvegicus) have originated. However recent fossil analyses pointed to their origin in southern China. Moreover, whereas analyses of fossils dated the species' origin as ∼1.2–1.6 million years ago (Mya), molecular analyses yielded ∼0.5–2.9 Mya. Here, to study the geographic origin of the Norway rat and its spread across the globe we analyzed new and all published mitochondrial DNA cytochrome-b (cyt-b; N = 156) and D-loop (N = 212) sequences representing wild rats from four continents and select inbred strains. Our results are consistent with an origin of the Norway rat in southern China ∼1.3 Mya, subsequent prehistoric differentiation and spread in China and Asia from an initially weakly structured ancestral population, followed by further spread and differentiation across the globe during historic times. The recent spreading occurred mostly from derived European populations rather than from archaic Asian populations. We trace laboratory strains to wild lineages from Europe and North America and these represent a subset of the diversity of the rat; leaving Asian lineages largely untapped as a resource for biomedical models. By studying rats from Europe we made the observation that mtDNA diversity cannot be interpreted without consideration of pest control and, possibly, the evolution of rodenticide resistance. However, demographic models explored by forward-time simulations cannot fully explain the low mtDNA diversity of European rats and lack of haplotype sharing with their source from Asia. Comprehensive nuclear marker analyses of a larger sample of Norway rats representing the world are needed to better resolve the evolutionary history of wild rats and of laboratory rats, as well as to better understand the evolution of anticoagulant resistance.
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影响因子：
3.7
作者：
Aplin KP;Suzuki H;Chinen AA;Chesser RT;Ten Have J;Donnellan SC;Austin J;Frost A;Gonzalez JP;Herbreteau V;Catzeflis F;Soubrier J;Fang YP;Robins J;Matisoo-Smith E;Bastos AD;Maryanto I;Sinaga MH;Denys C;Van Den Bussche RA;Conroy C;Rowe K;Cooper A
通讯作者：
Cooper A
影响因子：
56.9
作者：
JACKSON, WB;KAUKEINE.D
通讯作者：
KAUKEINE.D
影响因子：
2.5
作者：
Kohn, MH;Pelz, JH
通讯作者：
Pelz, JH
DOI：
10.1073/pnas.97.14.7911
发表时间：
2000-07-05
影响因子：
11.1
作者：
Kohn, MH;Pelz, HJ;Wayne, RK
通讯作者：
Wayne, RK
影响因子：
10.7
作者：
Drummond, Alexei J.;Suchard, Marc A.;Rambaut, Andrew
通讯作者：
Rambaut, Andrew