Amnion-derived stem cells: in quest of clinical applications.
Amnion-derived stem cells: in quest of clinical applications.
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DOI：
10.1186/scrt66
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发表时间：
2011-05-19
影响因子：
7.5
通讯作者：
Miki T
中科院分区：
文献类型：
--
作者：
Miki T
在再生医学领域，人类围产期干细胞作为具有临床应用潜力的干细胞受到极大关注。围产期干细胞可以从人类废弃的胎盘中分离得到，具有取材方便、伦理问题少、DNA损伤小等优点，许多研究表明胎盘来源的细胞具有多能分化等干细胞特性，尤其是羊膜上皮细胞。足月人羊膜上皮含有相对大量的干细胞标记阳性细胞作为成体干细胞来源。在这篇综述中，我们介绍了为什么这么多的AE细胞具有干细胞特性的模型理论。我们还描述了以前的工作有关的治疗应用和讨论的AE细胞的多能性和潜在的陷阱，为胚胎干细胞的研究。
In the promising field of regenerative medicine, human perinatal stem cells are of great interest as potential stem cells with clinical applications. Perinatal stem cells could be isolated from normally discarded human placentae, which are an ideal cell source in terms of availability, the fewer number of ethical concerns, less DNA damage, and so on. Numerous studies have demonstrated that some of the placenta-derived cells possess stem cell characteristics like pluripotent differentiation ability, particularly in amniotic epithelial (AE) cells. Term human amniotic epithelium contains a relatively large number of stem cell marker-positive cells as an adult stem cell source. In this review, we introduce a model theory of why so many AE cells possess stem cell characteristics. We also describe previous work concerning the therapeutic applications and discuss the pluripotency of the AE cells and potential pitfalls for amnion-derived stem cell research.
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影响因子：
2.7
作者：
Banas, Richard Allan;Trumpower, Catherine;Zeevi, Adriana
通讯作者：
Zeevi, Adriana
影响因子：
5.2
作者：
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影响因子：
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作者：
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DOI：
10.1098/rstb.2005.1707
发表时间：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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