Altered resting-state functional connectivity of thalamus in earthquake-induced posttraumatic stress disorder: A functional magnetic resonance imaging study
Altered resting-state functional connectivity of thalamus in earthquake-induced posttraumatic stress disorder: A functional magnetic resonance imaging study
复制标题
地震诱发的创伤后应激障碍中丘脑静息态功能连接的改变：功能磁共振成像研究
DOI：
10.1016/j.brainres.2011.07.016
复制
发表时间：
2011-09
期刊：
影响因子：
2.9
通讯作者：
Jiang, Tianzi
中科院分区：
文献类型：
--
作者：
Yin, Yan;Jin, Hua;Wong, Cheewing;Gong, Qiyong;Li, Lingjiang;Jin, Changfeng;Hu, Xiaolei;Duan, Lian;Li, Zexuan;Song, Ming;Chen, Han;Feng, Bo;Jiang, Tianzi
背景创伤后应激障碍(PTSD)患者存在丘脑功能障碍，提示丘脑可能参与了PTSD的发病机制。然而，还没有研究探索静息状态下丘脑和其他大脑区域之间的功能连接。本研究的目的是探讨四川地震后新近发生的药物治疗未用药的创伤后应激障碍患者丘脑静息状态下的功能连通性。方法采用3T功能磁共振成像(FMRI)对54例患有创伤后应激障碍的患者和72例年龄、性别相匹配的正常对照进行静息状态下的功能磁共振扫描。采用基于感兴趣区(ROI)的功能连接性分析来确定两组之间丘脑功能连接性的潜在差异。结果在PTSD组中，丘脑-ROI与特定脑区(包括右侧额内侧回和左侧前扣带回)的正功能连接性降低。重要的是，我们还发现PTSD患者的丘脑-ROI与双侧额下回和左额中回、左侧顶下小叶以及右侧楔前回的正功能连接比没有PTSD的创伤对照组增加。结论这些结果为连接丘脑和皮质的异常静息状态功能连接提供了证据，可能参与了PTSD的潜在病理过程。
BACKGROUNDThalamic dysfunction has been found in patients with posttraumatic stress disorder (PTSD), suggesting that the thalamus may be implicated in the etiology of PTSD. However, no studies have explored the functional connectivity between the thalamus and other brain regions during resting-state. The objective of the present study was to investigate the resting-state functional connectivity of the thalamus in recent onset medication-naive PTSD sufferers who went through an earthquake in the Sichuan province of China.METHODSFifty-four participants with PTSD and seventy-two age and gender matched traumatized controls without PTSD recruited from the 2008 Sichuan earthquake were scanned by 3T functional magnetic resonance imaging (fMRI) in resting state. Region of interest (ROI)-based functional connectivity analysis was employed to identify the potential differences in the functional connectivity of the thalamus between the two groups.RESULTSIn the PTSD group, the thalamus-ROIs showed decreased positive functional connectivity to particular brain regions including right medial frontal gyrus and left anterior cingulate cortex. Importantly, we also found increased positive functional connectivity of thalamus-ROIs with bilateral inferior frontal and left middle frontal gyri, left inferior parietal lobule as well as right precuneus in the PTSD participants when compared to traumatized controls without PTSD.CONCLUSIONThe results provide evidence that abnormal resting state functional connections linking the thalamus to cortical regions may be involved in the underlying pathology in PTSD.
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DOI：
10.1523/jneurosci.22-01-00324.2002
发表时间：
2002-01
期刊：
The Journal of Neuroscience
影响因子：
--
作者：
J. Rosenkranz;A. Grace;Mh;J. A. R. We;Nicole Macmurdo;Christine A. Wyant;B. Lowry
通讯作者：
J. Rosenkranz;A. Grace;Mh;J. A. R. We;Nicole Macmurdo;Christine A. Wyant;B. Lowry
DOI：
--
发表时间：
2007
期刊：
--
影响因子：
--
作者：
M. Rubin;J. Safdieh
通讯作者：
M. Rubin;J. Safdieh
DOI：
--
发表时间：
--
期刊：
--
影响因子：
--
作者：
Tao Blockindeng
通讯作者：
Tao Blockindeng
影响因子：
16.2
作者：
LaBar, KS;Gatenby, JC;Phelps, EA
通讯作者：
Phelps, EA
影响因子：
1.9
作者：
Milad, MR;Vidal-Gonzalez, I;Quirk, GJ
通讯作者：
Quirk, GJ