Overlapping Autoimmune Syndromes in Patients With Glial Fibrillary Acidic Protein Antibodies.
Overlapping Autoimmune Syndromes in Patients With Glial Fibrillary Acidic Protein Antibodies.
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胶质纤维酸性蛋白抗体患者的重叠自身免疫综合征
DOI：
10.3389/fneur.2018.00251
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发表时间：
2018
影响因子：
3.4
通讯作者：
Gao C
中科院分区：
文献类型：
--
作者：
Yang X;Xu H;Ding M;Huang Q;Chen B;Yang H;Liu T;Long Y;Gao C
Background Glial fibrillary acidic protein (GFAP) astrocytopathy, an autoimmune central nervous system disorder with a specific GFAP-IgG, often coexists with other antibodies. Objective The aim of this article was to study overlapping syndromes in autoimmune GFAP astrocytopathy. Methods Antibody was detected by indirect immunofluorescence assay. Patient data were analyzed retrospectively. Results Thirty patients with positive GFAP-IgG were included, of whom 10 were defined as overlapping syndrome. Four patients with positive aquaporin-4 (AQP4)-IgG, two with N-methyl-d-aspartate receptor-IgG, three with unknown neuronal antibodies, and one with double AQP4 and myelin oligodendrocyte glycoprotein-IgG were identified. GFAP-IgG and other specific antibodies occurred simultaneously at the initial attack in eight patients. The main symptoms included fever, headache, ataxia, psychosis, hypersomnia, dyskinesia, dementia, seizure, myelitis, and optical symptoms. Brain magnetic resonance imaging in four patients revealed characteristic radial enhancing patterns in the white matter. Cortical abnormalities were found in four patients. Other brain abnormalities occurred in the hypothalamus, midbrain, pons, medulla, cerebellum, and meninges. Six patients exhibited lesions in the spinal cord. In a subgroup study, patients with overlapping syndrome were younger at onset than those with non-overlapping syndrome. Conclusion Overlapping antibodies are common in GFAP astrocytopathy.
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影响因子：
5.8
作者：
Jarius, Sven;Jacobi, Christian;Wildemann, Brigitte
通讯作者：
Wildemann, Brigitte
影响因子：
9.9
作者：
Wingerchuk DM;Banwell B;Bennett JL;Cabre P;Carroll W;Chitnis T;de Seze J;Fujihara K;Greenberg B;Jacob A;Jarius S;Lana-Peixoto M;Levy M;Simon JH;Tenembaum S;Traboulsee AL;Waters P;Wellik KE;Weinshenker BG;International Panel for NMO Diagnosis
通讯作者：
International Panel for NMO Diagnosis
DOI：
10.1111/bpa.12099
发表时间：
2014-01
期刊：
Brain pathology (Zurich, Switzerland)
影响因子：
--
作者：
Lucchinetti CF;Guo Y;Popescu BF;Fujihara K;Itoyama Y;Misu T
通讯作者：
Misu T
DOI：
10.1016/s1474-4422(15)00401-9
发表时间：
2016-04
期刊：
The Lancet. Neurology
影响因子：
--
作者：
Graus F;Titulaer MJ;Balu R;Benseler S;Bien CG;Cellucci T;Cortese I;Dale RC;Gelfand JM;Geschwind M;Glaser CA;Honnorat J;Höftberger R;Iizuka T;Irani SR;Lancaster E;Leypoldt F;Prüss H;Rae-Grant A;Reindl M;Rosenfeld MR;Rostásy K;Saiz A;Venkatesan A;Vincent A;Wandinger KP;Waters P;Dalmau J
通讯作者：
Dalmau J
影响因子：
11.2
作者：
Titulaer, Maarten J.;Hoeftberger, Romana;Iizuka, Takahiro;Leypoldt, Frank;McCracken, Lindsey;Cellucci, Tania;Benson, Leslie A.;Shu, Huidy;Irioka, Takashi;Hirano, Makito;Singh, Gagandeep;Cobo Calvo, Alvaro;Kaida, Kenichi;Morales, Pamela S.;Wirtz, Paul W.;Yamamoto, Tomotaka;Reindl, Markus;Rosenfeld, Myrna R.;Graus, Francesc;Saiz, Albert;Dalmau, Josep
通讯作者：
Dalmau, Josep