Targeting the Subventricular Zone to Promote Myelin Repair in the Aging Brain.
Targeting the Subventricular Zone to Promote Myelin Repair in the Aging Brain.
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靶向室内区域以促进衰老大脑的髓磷脂修复。
DOI：
10.3390/cells11111809
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发表时间：
2022-05-31
期刊：
影响因子：
6
通讯作者：
Azim, Kasum
中科院分区：
文献类型：
--
作者：
Butt, Arthur Morgan;Rivera, Andrea Dominico;Fulton, Daniel;Azim, Kasum
脑室下区（SVZ）是成人前脑中最大、最活跃的生发区。SVZ的神经干细胞（NSCs）终生产生嗅觉中间神经元，并保留产生中枢神经系统髓鞘细胞少突胶质细胞（OLs）的内在能力。ol和髓磷脂是脱髓鞘疾病如多发性硬化症（MS）的靶点。髓鞘再生依赖于少突胶质祖细胞（OPCs）增殖、迁移和最终分化为髓鞘ol的能力。在衰老过程中，OPCs的再生能力逐渐下降，随之而来的ol和髓磷脂的损失是MS和其他衰老相关病理（包括阿尔茨海默病（AD）和中风）中认知能力下降和髓鞘再生失败的一个因素。与年龄相关的少突胶质发生减少尚未完全表征，但已知反映了影响OPCs对促分化刺激作出反应能力的内在和环境因素的变化。值得注意的是，除了实质OPCs外，svz衍生的OPCs是髓鞘再生成ol的重要来源。在这篇综述中，我们简要讨论了svz来源的OPCs和实质OPCs对脱髓鞘反应的差异，并强调了与它们在体内研究相关的挑战，以及它们如何针对老年大脑进行再生治疗。
The subventricular zone (SVZ) is the largest and most active germinal zone in the adult forebrain. Neural stem cells (NSCs) of the SVZ generate olfactory interneurons throughout life and retain the intrinsic ability to generate oligodendrocytes (OLs), the myelinating cells of the central nervous system. OLs and myelin are targets in demyelinating diseases such as multiple sclerosis (MS). Remyelination is dependent on the ability of oligodendrocyte progenitor cells (OPCs) to proliferate, migrate, and terminally differentiate into myelinating OLs. During aging, there is a gradual decrease in the regenerative capacity of OPCs, and the consequent loss of OLs and myelin is a contributing factor in cognitive decline and the failure of remyelination in MS and other pathologies with aging contexts, including Alzheimer’s disease (AD) and stroke. The age-related decrease in oligodendrogenesis has not been fully characterised but is known to reflect changes in intrinsic and environmental factors affecting the ability of OPCs to respond to pro-differentiation stimuli. Notably, SVZ-derived OPCs are an important source of remyelinating OLs in addition to parenchymal OPCs. In this mini-review, we briefly discuss differences between SVZ-derived and parenchymal OPCs in their responses to demyelination and highlight challenges associated with their study in vivo and how they can be targeted for regenerative therapies in the aged brain.
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DOI：
10.1007/978-981-13-9913-8_5
发表时间：
2019-01-01
期刊：
NEUROGLIA IN NEURODEGENERATIVE DISEASES
影响因子：
--
作者：
Butt, Arthur M.;Papanikolaou, Maria;Rivera, Andrea
通讯作者：
Rivera, Andrea
影响因子：
11.8
作者：
James OG;Selvaraj BT;Magnani D;Burr K;Connick P;Barton SK;Vasistha NA;Hampton DW;Story D;Smigiel R;Ploski R;Brophy PJ;Ffrench-Constant C;Lyons DA;Chandran S
通讯作者：
Chandran S
影响因子：
5.3
作者：
Cayre M;Falque M;Mercier O;Magalon K;Durbec P
通讯作者：
Durbec P
影响因子：
9.8
作者：
Azim K;Angonin D;Marcy G;Pieropan F;Rivera A;Donega V;Cantù C;Williams G;Berninger B;Butt AM;Raineteau O
通讯作者：
Raineteau O
影响因子：
16.6
作者：
Donega V;van der Geest AT;Sluijs JA;van Dijk RE;Wang CC;Basak O;Pasterkamp RJ;Hol EM
通讯作者：
Hol EM