Mechanotransduction by hair cells: models, molecules, and mechanisms.

Mechanotransduction by hair cells: models, molecules, and mechanisms.
复制标题

DOI:
10.1016/j.cell.2009.09.010
复制
发表时间:
2009-10-02
期刊:
影响因子:
64.5
通讯作者:
Müller U
Müller U
中科院分区:
生物学1区
文献类型:
--
作者:
Gillespie PG;Müller U

文献摘要

参考文献

被引文献

相似文献

机械力转换,将机械力转化为电信号,使生物体能够听到,记录运动和重力,检测触摸,并感知细胞体积和形状的变化。内耳中的毛细胞是检测声音和头部运动的专门的机械感受器细胞。毛细胞的机械传导机制非常敏感,可以在亚毫秒的时间尺度上对微小的物理位移做出反应。最近发现的几个分子成分的毛细胞的mechanotransduction机械提供了一个新的框架,生物物理数据的解释,并需要修订现行的mechanotransduction模型。
Mechanotransduction, the transformation of mechanical force into an electrical signal, allows living organisms to hear, register movement and gravity, detect touch, and sense changes in cell volume and shape. Hair cells in the inner ear are specialized mechanoreceptor cells that detect sound and head movement. The mechanotransduction machinery of hair cells is extraordinarily sensitive and responds to minute physical displacements on a submillisecond timescale. The recent discovery of several molecular constituents of the mechanotransduction machinery of hair cells provides a new framework for the interpretation of biophysical data and necessitates revision of prevailing models of mechanotransduction.
DOI: 10.1529/biophysj.107.123257
发表时间: 2008-04-01
影响因子: 3.4
作者:
Beurg, Maryline;Nam, Jong-Hoon;Fettiplace, Robert
通讯作者: Fettiplace, Robert
DOI: 10.1098/rspb.1997.0087
发表时间: 1997-04-22
影响因子: 4.7
作者:
Geleoc, GSG;Lennan, GWT;Kros, CJ
通讯作者: Kros, CJ
DOI: 10.1016/s0006-3495(79)85267-4
发表时间: 1979-01-01
影响因子: 3.4
作者:
COREY, DP;HUDSPETH, AJ
通讯作者: HUDSPETH, AJ
DOI: 10.1073/pnas.2334417100
发表时间: 2003-11-25
影响因子: 11.1
作者:
Belyantseva, IA;Boger, ET;Friedman, TB
通讯作者: Friedman, TB
DOI: 10.1016/j.neuron.2008.02.028
发表时间: 2008-05-08
期刊: NEURON
影响因子: 16.2
作者:
Dallos, Peter;Wu, Xudong;Zuo, Jian
通讯作者: Zuo, Jian