Increased Abundance of Clostridium and Fusobacterium in Gastric Microbiota of Patients with Gastric Cancer in Taiwan.
Increased Abundance of Clostridium and Fusobacterium in Gastric Microbiota of Patients with Gastric Cancer in Taiwan.
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DOI：
10.1038/s41598-017-18596-0
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发表时间：
2018-01-09
影响因子：
4.6
通讯作者：
Li C
中科院分区：
文献类型：
--
作者：
Hsieh YY;Tung SY;Pan HY;Yen CW;Xu HW;Lin YJ;Deng YF;Hsu WT;Wu CS;Li C
幽门螺杆菌被认为是胃癌的主要危险因素。然而，大约一半的胃炎患者是H阴性的。pylori感染和H. pylori在癌症患者中减少。在目前的研究中，我们分析了胃炎、肠上皮化生和胃癌患者胃上皮相关的细菌种类，以确定其他潜在的致病菌。胃炎患者和肠上皮化生患者的微生物群总体组成相似。H. pylori阳性率占非癌组的一半，H.幽门螺杆菌阴性的患者为伯克霍尔德菌属、肠杆菌属和勒克莱尔菌属。这些细菌的丰度在癌症组和非癌症组之间是相似的，而H。pylori在癌症组中显著降低。相反，梭菌属、梭杆菌属和乳杆菌属物种在胃癌患者中经常是丰富的，证明了胃癌特异性细菌特征。受试者工作特征曲线分析显示大肠梭菌和具核梭杆菌对胃癌具有诊断能力。我们的研究结果表明，在胃癌患者的胃微环境中经常被梭菌和梭杆菌定植。
Helicobacter pylori is recognised as a main risk factor for gastric cancer. However, approximately half of the patients with gastritis are negative for H. pylori infection, and the abundance of H. pylori decreases in patients with cancer. In the current study, we profiled gastric epithelium-associated bacterial species in patients with gastritis, intestinal metaplasia, and gastric cancer to identify additional potential pathogenic bacteria. The overall composition of the microbiota was similar between the patients with gastritis and those with intestinal metaplasia. H. pylori was present in half of the non-cancer group, and the dominant bacterial species in the H. pylori-negative patients were Burkholderia, Enterobacter, and Leclercia. The abundance of those bacteria was similar between the cancer and non-cancer groups, whereas the frequency and abundance of H. pylori were significantly lower in the cancer group. Instead, Clostridium, Fusobacterium, and Lactobacillus species were frequently abundant in patients with gastric cancer, demonstrating a gastric cancer-specific bacterial signature. A receiver operating characteristic curve analysis showed that Clostridium colicanis and Fusobacterium nucleatum exhibited a diagnostic ability for gastric cancer. Our findings indicate that the gastric microenvironment is frequently colonised by Clostridium and Fusobacterium in patients with gastric cancer.
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影响因子：
4.6
作者：
Aviles-Jimenez F;Vazquez-Jimenez F;Medrano-Guzman R;Mantilla A;Torres J
通讯作者：
Torres J
影响因子：
3.4
作者：
Conrads, G;Citron, DM;Goldstein, EJC
通讯作者：
Goldstein, EJC
影响因子：
9.4
作者：
Keren, Yaniv;Keshet, Doron;Hussein, Khetam
通讯作者：
Hussein, Khetam
影响因子：
4.6
作者：
Li TP;Wong WP;Chen LC;Su CY;Chen LG;Liu DZ;Ho HO;Sheu MT
通讯作者：
Sheu MT
影响因子：
4.3
作者：
Li, Yu-Yuan;Ge, Quan-Xing;Nie, Yu-Qiang
通讯作者：
Nie, Yu-Qiang