A global phylogenetic analysis in order to determine the host species and geography dependent features present in the evolution of avian H9N2 influenza hemagglutinin.
A global phylogenetic analysis in order to determine the host species and geography dependent features present in the evolution of avian H9N2 influenza hemagglutinin.
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作者：
Dalby AR;Iqbal M
对 1966 年至 2012 年间收集的所有 H9N2 血凝素序列进行了完整的系统发育分析，以构建血凝素蛋白的地理和宿主特异性进化的图景。为了提高输出数据的质量和适用性，根据位置和宿主物种将序列分为子集。血凝素的系统发育分析表明，该蛋白质在中国和中东之间具有不同的谱系，并且这两个地区的野生鸟类都保留了 H9 分子的独特形式，与祖先血凝素具有相同的谱系。这些结果进一步证明了目前主要的 H9N2 血凝素谱系可能起源于中国南方的假设。该研究还表明，存在影响本分析和任何类似分析可靠性的抽样问题。这引发了人们对 H9N2 的监测以及是否需要在环境中进行更广泛的病毒采样的疑问。该分析的结果也与血凝素主要通过偶尔的选择事件间断的中性漂移进化的模型一致。这些选择性事件在中东、韩国和中国产生了当前不同的血统模式。这种解释与现有研究一致，这些研究表明存在广泛的国家内序列进化。
A complete phylogenetic analysis of all of the H9N2 hemagglutinin sequences that were collected between 1966 and 2012 was carried out in order to build a picture of the geographical and host specific evolution of the hemagglutinin protein. To improve the quality and applicability of the output data the sequences were divided into subsets based upon location and host species. The phylogenetic analysis of hemagglutinin reveals that the protein has distinct lineages between China and the Middle East, and that wild birds in both regions retain a distinct form of the H9 molecule, from the same lineage as the ancestral hemagglutinin. The results add further evidence to the hypothesis that the current predominant H9N2 hemagglutinin lineage might have originated in Southern China. The study also shows that there are sampling problems that affect the reliability of this and any similar analysis. This raises questions about the surveillance of H9N2 and the need for wider sampling of the virus in the environment. The results of this analysis are also consistent with a model where hemagglutinin has predominantly evolved by neutral drift punctuated by occasional selection events. These selective events have produced the current pattern of distinct lineages in the Middle East, Korea and China. This interpretation is in agreement with existing studies that have shown that there is widespread intra-country sequence evolution.
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DOI：
10.1093/bioinformatics/8.3.275
发表时间：
1992-06-01
期刊：
COMPUTER APPLICATIONS IN THE BIOSCIENCES
影响因子：
--
作者：
JONES, DT;TAYLOR, WR;THORNTON, JM
通讯作者：
THORNTON, JM
影响因子：
4.8
作者：
Abdel-Moneim, Ahmed S.;Afifi, Manal A.;El-Kady, Magdy F.
通讯作者：
El-Kady, Magdy F.
影响因子：
5.4
作者：
Fusaro, Alice;Monne, Isabella;Cattoli, Giovanni
通讯作者：
Cattoli, Giovanni
影响因子：
9.4
作者：
Butt, KM;Smith, GJD;Guan, Y
通讯作者：
Guan, Y
影响因子：
4.9
作者：
Lam, Tommy Tsan-Yuk;Hon, Chung-Chau;Leung, Frederick Chi-Ching
通讯作者：
Leung, Frederick Chi-Ching