Iron status is associated with asthma and lung function in US women.
Iron status is associated with asthma and lung function in US women.
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DOI：
10.1371/journal.pone.0117545
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Matsui EC
中科院分区：
文献类型：
--
作者：
Brigham EP;McCormack MC;Takemoto CM;Matsui EC
哮喘和缺铁是常见病症。铁状态是否影响哮喘风险尚不清楚。确定铁状态与哮喘、肺功能和肺部炎症之间的关系。在国家健康和营养检查调查中，对 20-49 岁女性的铁状态指标（血清铁蛋白、血清可溶性转铁蛋白受体 (sTfR) 和 sTfR/log10 铁蛋白（sTfR-F 指数））与哮喘、肺功能和肺部炎症之间的关系进行了检查。 NHANES 调查设计的逻辑回归、线性回归和二次回归模型用于评估铁状态与哮喘相关结果之间的关联，并根据种族/民族、年龄、吸烟状况、收入和体重指数进行调整。大约 16% 的人报告一生有哮喘病史，9% 的人报告当前患有哮喘，5% 的人报告最近有哮喘发作/发作 (n = 2906)。铁蛋白（铁储存）增加与终生哮喘、当前哮喘和哮喘发作/发作的几率降低相关，铁蛋白与铁储存线性相关（20-300ng/ml）。铁蛋白的最高五分位数（>76 ng/ml）也与哮喘发病率降低相关。铁蛋白水平与 FEV1 无关。 sTfR-F 指数和 sTfR 值的增加分别表明身体铁需求较低和组织铁需求较高，与 FEV1 降低相关，但两者均与哮喘无关。所有铁指数均与 FeNO 无关。在美国女性中，较高的铁储备与哮喘呈负相关，较低的身体铁含量和较高的组织铁需求与较低的肺功能相关。总之，这些发现表明铁状况可能在美国女性的哮喘和肺功能中发挥作用。
Asthma and iron deficiency are common conditions. Whether iron status affects the risk of asthma is unclear. To determine the relationship between iron status and asthma, lung function, and pulmonary inflammation. Relationships between measures of iron status (serum ferritin, serum soluble transferrin receptor (sTfR), and sTfR/log10ferritin (sTfR-F Index)) and asthma, lung function, and pulmonary inflammation were examined in women 20-49 years in the National Health and Nutrition Examination Survey. Logistic, linear, and quadratic regression models accounting for the survey design of NHANES were used to evaluate associations between iron status and asthma-related outcomes and were adjusted for race/ethnicity, age, smoking status, income, and BMI. Approximately 16% reported a lifetime history of asthma, 9% reported current asthma, and 5% reported a recent asthma episode/attack (n = 2906). Increased ferritin (iron stores) was associated with decreased odds of lifetime asthma, current asthma, and asthma attacks/episodes in the range of ferritin linearly correlated with iron stores (20-300ng/ml). The highest quintile of ferritin (>76 ng/ml) was also associated with a decreased odds of asthma. Ferritin levels were not associated with FEV1. Increased values of the sTfR-F Index and sTfR, indicating lower body iron and higher tissue iron need, respectively, were associated with decreased FEV1, but neither was associated with asthma. None of the iron indices were associated with FeNO. In US women, higher iron stores were inversely associated with asthma and lower body iron and higher tissue iron need were associated with lower lung function. Together, these findings suggest that iron status may play a role in asthma and lung function in US women.
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DOI：
10.1084/jem.174.2.459
发表时间：
1991-08-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Alford CE;King TE Jr;Campbell PA
通讯作者：
Campbell PA
影响因子：
2.6
作者：
Bucca, C.;Culla, B.;Rolla, G.
通讯作者：
Rolla, G.
影响因子：
2.6
作者：
Howard LS;Watson GM;Wharton J;Rhodes CJ;Chan K;Khengar R;Robbins PA;Kiely DG;Condliffe R;Elliott CA;Pepke-Zaba J;Sheares K;Morrell NW;Davies R;Ashby D;Gibbs JS;Wilkins MR
通讯作者：
Wilkins MR
影响因子：
1.7
作者：
Kon, Noriko;Tanaka, Kyoko;Shimizu, Toshiaki
通讯作者：
Shimizu, Toshiaki
影响因子：
6.8
作者：
Castel, Rob;Tax, Martine G. H. M.;Berendes, Paul B.
通讯作者：
Berendes, Paul B.