Exosomes and Their Role in Cancer Progression.
Exosomes and Their Role in Cancer Progression.
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外泌体及其在癌症进展中的作用。
DOI：
10.3389/fonc.2021.639159
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发表时间：
2021
影响因子：
4.7
通讯作者：
Zhou J
中科院分区：
文献类型：
--
作者：
Liu Y;Shi K;Chen Y;Wu X;Chen Z;Cao K;Tao Y;Chen X;Liao J;Zhou J
细胞外囊泡外泌体通过向受体细胞转运蛋白质、脂质、核酸等物质，激活或抑制多种信号通路。此外，外泌体被认为以多种方式参与来自不同组织来源的肿瘤的发生和进展，包括肿瘤微环境的重塑，促进血管生成、转移和侵袭，以及调节肿瘤细胞的免疫逃逸。然而，外泌体参与这些不同过程的精确分子机制尚不清楚。本文就肿瘤细胞源性外泌体在肿瘤进展中的研究进展作一综述。我们还讨论了外泌体联合纳米工程化疗药物在癌症治疗中的应用前景。
Exosomes from extracellular vesicles can activate or inhibit various signaling pathways by transporting proteins, lipids, nucleic acids and other substances to recipient cells. In addition, exosomes are considered to be involved in the development and progression of tumors from different tissue sources in numerous ways, including remodeling of the tumor microenvironment, promoting angiogenesis, metastasis, and invasion, and regulating the immune escape of tumor cells. However, the precise molecular mechanisms by which exosomes participate in these different processes remains unclear. In this review, we describe the research progress of tumor cell-derived exosomes in cancer progression. We also discuss the prospects of the application of exosomes combined with nanoengineered chemotherapeutic drugs in the treatment of cancer.
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