Bone marrow mesenchymal stem cells: Aging and tissue engineering applications to enhance bone healing.
Bone marrow mesenchymal stem cells: Aging and tissue engineering applications to enhance bone healing.
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DOI：
10.1016/j.biomaterials.2018.06.026
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发表时间：
2019-05
期刊：
影响因子：
14
通讯作者：
Tuan RS
中科院分区：
文献类型：
--
作者：
Lin H;Sohn J;Shen H;Langhans MT;Tuan RS
骨具有良好的自然愈合能力，通常足以修复骨折和其他常见损伤。然而，骨骼的性质在一生中都会发生变化，随着年龄的增长，骨病的发生率会增加，骨折愈合能力也会受到影响，这就需要有效的治疗方法来促进骨再生。成人间充质干细胞(MSCs)用于骨修复的治疗潜力早已被提出和研究。MSCs的作用可能包括直接分化为骨细胞，吸引和招募其他细胞，或者通过产生营养生长因子来创造再生环境。随着全身性衰老，MSCs也会经历功能衰退，这在最近的一些研究中已经得到了很好的研究。在这篇综述中，我们首先描述了MSCs在衰老过程中的变化，并讨论了这些变化如何影响骨再生。接下来，我们将回顾目前骨组织工程的研究成果，它被认为是一种有前途的、可行的骨结构和功能修复的治疗方案。特别强调了骨髓间充质干细胞和生物支架的重要性。最后，讨论了预防MSC衰老和衰老MSC的可能途径。
Bone has well documented natural healing capacity that normally is sufficient to repair fractures and other common injuries. However, the properties of bone change throughout life, and aging is accompanied by increased incidence of bone diseases and compromised fracture healing capacity, which necessitate effective therapies capable of enhancing bone regeneration. The therapeutic potential of adult mesenchymal stem cells (MSCs) for bone repair has been long proposed and examined. Actions of MSCs may include direct differentiation to become bone cells, attraction and recruitment of other cells, or creation of a regenerative environment via production of trophic growth factors. With systemic aging, MSCs also undergo functional decline, which has been well investigated in a number of recent studies. In this review, we first describe the changes in MSCs during aging and discuss how these alterations can affect bone regeneration. We next review current research findings on bone tissue engineering, which is considered a promising and viable therapeutic solution for structural and functional restoration of bone. In particular, the importance of MSCs and bioscaffolds is highlighted. Finally, potential approaches for the prevention of MSC aging and the rejuvenation of aged MSC are discussed.
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影响因子：
17.1
作者：
Biressi S;Miyabara EH;Gopinath SD;Carlig PM;Rando TA
通讯作者：
Rando TA
影响因子：
--
作者：
Bickford, Paula C.;Kaneko, Yuji;Shytle, R. Douglas
通讯作者：
Shytle, R. Douglas
影响因子：
6.2
作者：
Burge, Russel;Dawson-Hughes, Bess;Tosteson, Anna
通讯作者：
Tosteson, Anna
影响因子：
4
作者：
Baksh, Dolores;Boland, Genevieve M.;Tuan, Rocky S.
通讯作者：
Tuan, Rocky S.
影响因子：
3.4
作者：
Alvarez K;Nakajima H
通讯作者：
Nakajima H