Cellular kinases incorporated into HIV-1 particles: passive or active passengers?
Cellular kinases incorporated into HIV-1 particles: passive or active passengers?
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DOI：
10.1186/1742-4690-8-71
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发表时间：
2011-09-02
期刊：
影响因子：
3.3
通讯作者：
Briant L
中科院分区：
文献类型：
--
作者：
Giroud C;Chazal N;Briant L
磷酸化是调节蛋白质因子活性的主要机制之一。这种调节影响哺乳动物细胞的多种关键功能，包括信号转导、核质穿梭、大分子复合体组装、DNA结合和酶活性的调节等。为了确保它们在宿主中有效复制和繁殖的能力，病毒可能依赖于病毒蛋白的磷酸化来辅助其生命周期的不同步骤。几十年来，人们已经知道来自不同病毒家族的颗粒含有一定的蛋白激酶活性。虽然大型DNA病毒通常编码病毒激酶，但RNA病毒和更准确地说，逆转录病毒已经获得了劫持宿主细胞的信号机制并在萌芽时启动细胞激酶的能力。这种特性在十多年前就在HIV-1病毒上得到了证明。本文综述了HIV-1相关蛋白激酶的研究进展，并讨论了它们在逆转录病毒生命周期中的可能功能。
Phosphorylation is one of the major mechanisms by which the activities of protein factors can be regulated. Such regulation impacts multiple key-functions of mammalian cells, including signal transduction, nucleo-cytoplasmic shuttling, macromolecular complexes assembly, DNA binding and regulation of enzymatic activities to name a few. To ensure their capacities to replicate and propagate efficiently in their hosts, viruses may rely on the phosphorylation of viral proteins to assist diverse steps of their life cycle. It has been known for several decades that particles from diverse virus families contain some protein kinase activity. While large DNA viruses generally encode for viral kinases, RNA viruses and more precisely retroviruses have acquired the capacity to hijack the signaling machinery of the host cell and to embark cellular kinases when budding. Such property was demonstrated for HIV-1 more than a decade ago. This review summarizes the knowledge acquired in the field of HIV-1-associated kinases and discusses their possible function in the retroviral life cycle.
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