Excitatory superficial dorsal horn interneurons are functionally heterogeneous and required for the full behavioral expression of pain and itch.
Excitatory superficial dorsal horn interneurons are functionally heterogeneous and required for the full behavioral expression of pain and itch.
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DOI：
10.1016/j.neuron.2013.03.001
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发表时间：
2013-04-24
期刊：
影响因子：
16.2
通讯作者：
Basbaum AI
中科院分区：
文献类型：
--
作者：
Wang X;Zhang J;Eberhart D;Urban R;Meda K;Solorzano C;Yamanaka H;Rice D;Basbaum AI
背角中间神经元在何种程度上参与了疼痛和瘙痒信息的特定处理尚不清楚。在这里，我们报告说，loxp/cre介导的中枢神经系统删除TR 4，睾丸孤儿核受体，导致许多兴奋性中间神经元的损失在浅表背角，但保留初级传入和脊髓投射神经元。中间神经元损失与几乎完全不存在棘上整合的疼痛和瘙痒行为、机械退缩阈值升高和神经损伤诱导的机械超敏性损失相关，但对有害热的反射反应、神经损伤诱导的热超敏性和组织损伤诱导的热和机械超敏性是完整的。我们的结论是，背角兴奋性中间神经元的不同子集有助于组织和神经损伤引起的热和机械性疼痛，并完全表达的superraspinally-mediated疼痛和瘙痒行为不能产生单独的伤害感受器和神经感受器激活的投射神经元，兴奋性中间神经元的同时激活是必不可少的。
To what extent dorsal horn interneurons contribute to the modality specific processing of pain and itch messages is not known. Here we report that loxp/cre-mediated CNS deletion of TR4, a testicular orphan nuclear receptor, results in loss of many excitatory interneurons in the superficial dorsal horn, but preservation of primary afferents and spinal projection neurons. The interneuron loss is associated with a near complete absence of supraspinally-integrated pain and itch behaviors, elevated mechanical withdrawal thresholds and loss of nerve injury-induced mechanical hypersensitivity, but reflex responsiveness to noxious heat, nerve injury-induced heat hypersensitivity and tissue injury-induced heat and mechanical hypersensitivity are intact. We conclude that different subsets of dorsal horn excitatory interneurons contribute to tissue and nerve injury-induced heat and mechanical pain and that the full expression of supraspinally-mediated pain and itch behaviors cannot be generated solely by nociceptor and pruritoceptor activation of projection neurons; concurrent activation of excitatory interneurons is essential.
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