Two functional inhibitory circuits are comprised of a heterogeneous population of fast-spiking cortical interneurons.
Two functional inhibitory circuits are comprised of a heterogeneous population of fast-spiking cortical interneurons.
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DOI：
10.1016/j.neuroscience.2014.01.033
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发表时间：
2014-04-18
期刊：
影响因子：
3.3
通讯作者：
Huntsman MM
中科院分区：
文献类型：
--
作者：
Li P;Huntsman MM
皮质快速棘波(FS)中间神经元具有自体突触、突触和电突触，这些突触可调节对突触后靶点的快速、协调反应。虽然已知FS中间神经元参与许多不同的活动，但这一多功能中间神经元类别中的功能亚群仍有待确定。在本研究中，我们检测了初级躯体感觉(Barrel)皮质第四层的小白蛋白阳性FS中间神经元-这是一个众所周知的专门抑制功能的大脑区域。根据去极化序列中第一个动作电位的起始点，我们将FS中间神经元分为两大类：“延迟放电FS中间神经元(FSD)和早期放电FS中间神经元(FSE)”。动作电位放电的细微变化显示了这两种类型中的6种亚型：迟发性不适应(FSD-NAC)、迟发性口吃(FSD-STUT)、早发性口吃(FSE-STUT)、早发型-迟发性峰电位(FSE-LS)、早发型早峰电位(FSE-ES)和早发型适应性(FSE-AC)。使用以前用来区分神经细胞类型的生物物理标准，FSD和FSE类别显示出几个共同的生物物理和突触属性，这与皮质FS中间神经元类别中抑制功能的专一性概念相一致。
Cortical fast spiking (FS) interneurons possess autaptic, synaptic, and electrical synapses that serve to mediate a fast, coordinated response to their postsynaptic targets. While FS interneurons are known to participate in numerous and diverse actions, functional subgroupings within this multi-functional interneuron class remain to be identified. In the present study, we examined parvalbumin positive FS interneurons in layer 4 of the primary somatosensory (barrel) cortex - a brain region well-known for specialized inhibitory function. Here we show that FS interneurons fall into two broad categories identified by the onset of the first action potential in a depolarizing train as: “Delayed Firing FS interneurons (FSD) and Early Onset Firing FS interneurons (FSE). Subtle variations in action potential firing reveal 6 subtypes within these two categories: delayed non-accommodating (FSD-NAC), delayed stuttering (FSD-STUT), early onset stuttering (FSE-STUT), early onset-late spiking (FSE-LS), early onset early-spiking (FSE-ES), and early onset accommodating (FSE-AC). Using biophysical criteria previously employed to distinguish neuronal cell types, the FSD and FSE categories exhibit several shared biophysical and synaptic properties that coincide with the notion of specificity of inhibitory function within the cortical FS interneuron class.
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影响因子：
25
作者：
Cruikshank, Scott J.;Lewis, Timothy J.;Connors, Barry W.
通讯作者：
Connors, Barry W.
DOI：
10.1523/jneurosci.0058-09.2009
发表时间：
2009-03-18
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Karagiannis A;Gallopin T;Dávid C;Battaglia D;Geoffroy H;Rossier J;Hillman EM;Staiger JF;Cauli B
通讯作者：
Cauli B
影响因子：
3.3
作者：
Andrioli, A.;Alonso-Nanclares, L.;Defelipe, J.
通讯作者：
Defelipe, J.
影响因子：
34.7
作者：
Ascoli, Giorgio A.;Alonso-Nanclares, Lidia;Anderson, Stewart A.;Barrionuevo, German;Benavides-Piccione, Ruth;Burkhalter, Andreas;Buzsaki, Gyoergy;Cauli, Bruno;DeFelipe, Javier;Fairen, Alfonso;Feldmeyer, Dirk;Fishell, Gord;Fregnac, Yves;Freund, Tamas F.;Gardner, Daniel;Gardner, Esther P.;Goldberg, Jesse H.;Helmstaedter, Moritz;Hestrin, Shaul;Karube, Fuyuki;Kisvarday, Zoltan F.;Lambolez, Bertrand;Lewis, David A.;Marin, Oscar;Markram, Henry;Munoz, Alberto;Packer, Adam;Petersen, Carl C. H.;Rockland, Kathleen S.;Rossier, Jean;Rudy, Bernardo;Somogyi, Peter;Staiger, Jochen F.;Tamas, Gabor;Thomson, Alex M.;Toledo-Rodriguez, Maria;Wang, Yun;West, David C.;Yuste, Rafael
通讯作者：
Yuste, Rafael
影响因子：
2.5
作者：
Beierlein, M;Gibson, JR;Connors, BW
通讯作者：
Connors, BW