Immunological goings-on in visceral adipose tissue.

Immunological goings-on in visceral adipose tissue.
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DOI:
10.1016/j.cmet.2013.05.008
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发表时间:
2013-06-04
期刊:
影响因子:
29
通讯作者:
Mathis D
Mathis D
中科院分区:
生物学1区
文献类型:
--
作者:
Mathis D

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内脏脂肪组织的慢性、低度炎症和全身性炎症是最近肥胖和2型糖尿病发病率惊人平行上升之间的关键联系。一段时间以来,巨噬细胞被认为是肥胖诱导的脂肪组织炎症的关键参与者。最近,免疫系统的先天和适应性臂的其他细胞类型的分数已被建议在脂肪组织浸润中发挥积极或消极的作用。这篇文章回顾了这些新参与者的现有数据;讨论了实验的不确定性,不一致性和复杂性;并提出了一个最低限度的合成方案。
Chronic, low-grade inflammation of visceral adipose tissue, and systemically, is a critical link between recent strikingly parallel rises in the incidence of obesity and type-2 diabetes. Macrophages have been recognized for some time to be critical participants in obesity-induced inflammation of adipose-tissue. Of late, a score of other cell-types of the innate and adaptive arms of the immune system have been suggested to play a positive or negative role in adipose-tissue infiltrates. This piece reviews the existing data on these new participants; discusses experimental uncertainties, inconsistencies and complexities; and puts forward a minimalist synthetic scheme.
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