The Key Role of c-Fos for Immune Regulation and Bacterial Dissemination in Brucella Infected Macrophage.
The Key Role of c-Fos for Immune Regulation and Bacterial Dissemination in Brucella Infected Macrophage.
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DOI：
10.3389/fcimb.2018.00287
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发表时间：
2018
影响因子：
5.7
通讯作者：
Kim S
中科院分区：
文献类型：
--
作者：
Hop HT;Arayan LT;Huy TXN;Reyes AWB;Vu SH;Min W;Lee HJ;Rhee MH;Chang HH;Kim S
细胞癌基因c-Fos（c-Fos）是激活蛋白1（AP 1）的组成部分，AP 1是细胞的主要转录调节因子。通过siRNA处理抑制c-Fos信号传导导致TLR 4的显著诱导，TLR 4随后激活p38和ERK 1/2促分裂原活化蛋白激酶（MAPK）并增强F-肌动蛋白聚合，导致B增加。流产吞噬作用在B期间。在流产感染中，c-Fos信号被诱导，其激活下游天然免疫信号级联用于细菌清除。抑制c-Fos信号导致白细胞介素10（IL-10）的产生增加，这部分抑制了溶酶体介导的杀伤，导致B的存活增加。巨噬细胞内的流产。我们目前的证据表明，在B的增殖过程中发挥的调节作用的c-Fos途径。流产感染;然而，这与该途径的抗布鲁氏菌作用无关。另一个发现是c-Fos/TRAIL对感染细胞坏死的重要贡献，这是细菌传播的关键事件。这些数据提供了c-Fos参与宿主防御机制对抗布鲁氏菌感染和巨噬细胞传播细菌的机制。
The cellular oncogene c-Fos (c-Fos) is a component of activator protein 1 (AP1), a master transcriptional regulator of cells. The suppression of c-Fos signaling by siRNA treatment resulted in significant induction of TLR4, which subsequently activates p38 and ERK1/2 mitogen-activated protein kinases (MAPKs) and enhances F-actin polymerization, leading to an increase in B. abortus phagocytosis. During B. abortus infection, c-Fos signaling is induced, which activates the downstream innate-immunity signaling cascade for bacterial clearance. The inhibition of c-Fos signaling led to increased production of interleukin 10 (IL-10), which partially suppressed lysosome-mediated killing, resulting in increased survival of B. abortus inside macrophages. We present evidence of the regulatory role played by the c-Fos pathway in proliferation during B. abortus infection; however, this was independent of the anti-Brucella effect of this pathway. Another finding is the essential contribution of c-Fos/TRAIL to infected-cell necrosis, which is a key event in bacterial dissemination. These data provide the mechanism via which c-Fos participates in host defense mechanisms against Brucella infection and in bacterial dissemination by macrophages.
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影响因子：
3.7
作者：
Chen F;He Y
通讯作者：
He Y
DOI：
10.1084/jem.20031237
发表时间：
2004-01-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Doyle SE;O'Connell RM;Miranda GA;Vaidya SA;Chow EK;Liu PT;Suzuki S;Suzuki N;Modlin RL;Yeh WC;Lane TF;Cheng G
通讯作者：
Cheng G
影响因子：
3.1
作者：
JIANG, XS;BALDWIN, CL
通讯作者：
BALDWIN, CL
DOI：
10.1084/jem.20030088
发表时间：
2003-08-18
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Celli J;de Chastellier C;Franchini DM;Pizarro-Cerda J;Moreno E;Gorvel JP
通讯作者：
Gorvel JP
影响因子：
4.4
作者：
Cha SB;Lee WJ;Shin MK;Jung MH;Shin SW;Yoo AN;Kim JW;Yoo HS
通讯作者：
Yoo HS