Coexistence of Histologically Confirmed Hashimoto's Thyroiditis with Different Stages of Papillary Thyroid Carcinoma in a Consecutive Chinese Cohort.
Coexistence of Histologically Confirmed Hashimoto's Thyroiditis with Different Stages of Papillary Thyroid Carcinoma in a Consecutive Chinese Cohort.
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DOI：
10.1155/2014/769294
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发表时间：
2014
影响因子：
2.8
通讯作者：
Yang T
中科院分区：
文献类型：
--
作者：
Liu X;Zhu L;Cui D;Wang Z;Chen H;Duan Y;Shen M;Wu Y;Rong R;Zhang Z;Wang X;Chen J;Alexander EK;Yang T
目的。目的探讨桥本甲状腺炎（HT）与伴有或不伴有局部淋巴结转移（LNM）的甲状腺乳头状癌（PTC）各阶段的关系。方法。我们对南京医科大学第一附属医院2008-2013年甲状腺切除术患者进行回顾性研究。我们根据组织病理学证实的HT的存在对患者进行分类。比较mPTC（最大直径≤10 mm）、crPTC（临床相关PTC）和局部LNM发生率。结果。我们评估了6432例连续的甲状腺切除术。总共有1328份标本被确认为HT。该HT组PTC患病率为43.8%，显著高于非HT组。调整性别和年龄后，HT组PTC患病率仍较高。多因素分析显示，HT是PTC的危险因素，比值比为2.725 (95% CI, 2.390 ~ 3.109) （P < 0.001）。而HT与PTC的LNM无相关性。结论。HT与PTC各阶段患病率增加相关，与肿瘤大小、性别和年龄无关。相比之下，LNM定义的局部晚期疾病与HT无关。这些数据表明，HT与低风险PTC有关，并对疾病进一步进展具有潜在的保护性免疫作用。
Purpose. To determine the relationship between Hashimoto's thyroiditis (HT) and all stages of papillary thyroid carcinoma (PTC) with or without local lymph node metastasis (LNM). Methods. We conducted a retrospective study of thyroidectomies from 2008–2013 in First Affiliated Hospital of Nanjing Medical University. We categorized patients according to the presence of histopathologically proven HT. The prevalence of mPTC (maximum diameter ≤ 10 mm) and crPTC (clinical relevant PTC) and local LNM rates were compared. Results. We evaluated 6,432 consecutive thyroidectomies. In total, 1,328 specimens were confirmed as HT. The prevalence of PTC in this HT cohort was 43.8%, significantly higher than non-HT group. After adjustment of gender and age, the prevalence of PTC was still higher in HT group. HT was a risk factor for PTC in multivariate analysis with odds ratio 2.725 (95% CI, 2.390–3.109) (P < 0.001). However, no correlation was found between HT and LNM of PTC. Conclusion. HT was associated with an increased prevalence of all stages of PTC, independent of tumor size, gender, and age. In contrast, locally advanced disease defined by LNM was unrelated to HT. These data suggest an association of HT with low risk PTC and a potential protective immunologic effect from further disease progression.
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影响因子：
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作者：
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